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Cited 47 time in webofscience Cited 51 time in scopus
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3D printing of drug-loaded multi-shell rods for local delivery of bevacizumab and dexamethasone: A synergetic therapy for retinal vascular diseases SCIE SCOPUS

Title
3D printing of drug-loaded multi-shell rods for local delivery of bevacizumab and dexamethasone: A synergetic therapy for retinal vascular diseases
Authors
Won, J.Y.Kim, J.Gao, G.Kim, J.Jang, J.Park, Y.-H.Cho, D.-W.
Date Issued
2020-10
Publisher
ELSEVIER SCI LTD
Abstract
The clinical therapy for retinal vascular diseases requires repeated intravitreal injections of drugs owing to their short half-life, which imposes health and economic burdens on patients. Therefore, it is necessary to develop an advanced drug delivery system that can prolong the drug activity and minimize secondary complications. In this study, we developed a core/shell drug-loaded rod (drug rod) to deliver two types of drugs (bevacizumab (BEV) and dexamethasone (DEX)) from a single implant. The coaxial printing technique allowed BEV and DEX to be released with different kinetics at the same site by using a polymeric shell and a hydrogel core, respectively. The suggested printing technique facilitates the production of drug rods with various dimensions and drug concentrations, and the multi-layered design allows to adjust the release profile of dual drug-delivery system. The rod was injected in rat vitreous less invasively using a small-gauge needle. Further, we validated the efficacy of the implanted drug rods in inhibiting inflammatory responses and long-term suppression of neovascularization compared to the conventional intravitreal injection of BEV in animal model, indicating that the drug rods can be an alternative therapeutic approach for the treatment of various types of retinal vascular diseases. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
URI
https://oasis.postech.ac.kr/handle/2014.oak/104664
DOI
10.1016/j.actbio.2020.09.015
ISSN
1742-7061
Article Type
Article
Citation
ACTA BIOMATERIALIA, vol. 116, page. 174 - 185, 2020-10
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장진아JANG, JIN AH
Dept of Mechanical Enginrg
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