Protonation-Driven Aqueous Lyotropic Self-Assembly of Synthetic Six-Tail Lipidoids
SCIE
SCOPUS
- Title
- Protonation-Driven Aqueous Lyotropic Self-Assembly of Synthetic Six-Tail Lipidoids
- Authors
- Jennings, James; Carter, Matthew C. D.; SON, CHANG YUN; Cui, Qiang; Lynn, David, M.; Mahanthappa, Mahesh K.
- Date Issued
- 2020-07
- Publisher
- American Chemical Society
- Abstract
- We report the aqueous lyotropic mesophase behaviors of protonated amine-based "lipidoids," a class of synthetic lipid-like molecules that mirrors essential structural features of the multitail bacterial amphiphile lipid A. Small-angle X-ray scattering (SAXS) studies demonstrate that the protonation of the tetra(amine) headgroups of six-tail lipidoids in aqueous HCl, HNO3, H2SO4, and H3PO4 solutions variably drives their self-assembly into lamellar (L-alpha) and inverse micellar (I-II) lyotropic liquid crystals (LLCs), depending on acid identity and concentration, amphiphile tail length, and temperature. Lipidoid assemblies formed in H2SO4(aq) exhibit rare inverse body-centered cubic (BCC) and inverse face-centered cubic (FCC) micellar morphologies, the latter of which unexpectedly coexists with zero mean curvature L-alpha phases. Complementary atomistic molecular dynamics (MD) simulations furnish detailed insights into this unusual self-assembly behavior. The unique aqueous lyotropic mesophase behaviors of ammonium lipidoids originate in their dichotomous ability to adopt both inverse conical and chain-extended molecular conformations depending on the number of counterions and their identity, which lead to coexisting supramolecular assemblies with remarkably different mean interfacial curvatures.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/104024
- DOI
- 10.1021/acs.langmuir.0c01369
- ISSN
- 0743-7463
- Article Type
- Article
- Citation
- Langmuir, vol. 36, no. 28, page. 8240 - 8252, 2020-07
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