Open Access System for Information Sharing

Login Library

 

Article
Cited 2 time in webofscience Cited 2 time in scopus
Metadata Downloads

Structure-activity relationships of fluorene compounds inhibiting HCV variants SCIE SCOPUS

Title
Structure-activity relationships of fluorene compounds inhibiting HCV variants
Authors
Kim, Hee SunYou, YoungsuMun, JaegonGadhe, Changdev G.Moon, HeejoLee, Jae SeungPae, Ae NimKohara, MichinoriKeum, GyochangKim, Byeong MoonJANG, SUNG KEY
Date Issued
2020-02
Publisher
ELSEVIER
Abstract
Approximately 71 million people suffer from hepatitis C virus (HCV) infection worldwide. Persistent HCV infection causes liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, resulting in approximately 400,000 deaths annually. Effective direct-acting antiviral agents (DAAs) have been developed and are currently used for HCV treatment targeting the following three proteins: NS3/4A proteinase that cleaves the HCV polyprotein into various functional proteins, RNA-dependent RNA polymerase (designated as NS5B), and NS5A, which is required for the formation of double membrane vesicles serving as RNA replication organelles. At least one compound inhibiting NS5A is included in current HCV treatment regimens due to the high efficacy and low toxicity of drugs targeting NS5A. Here we report fluorene compounds showing strong inhibitory effects on GT 1b and 3a of HCV. Moreover, some compounds were effective against resistance-associated variants to DAAs. The structure-activity relationships of the compounds were analyzed. Furthermore, we investigated the molecular bases of the inhibitory activities of some compounds by the molecular docking method.
URI
https://oasis.postech.ac.kr/handle/2014.oak/103544
DOI
10.1016/j.antiviral.2019.104678
ISSN
0166-3542
Article Type
Article
Citation
ANTIVIRAL RESEARCH, vol. 174, 2020-02
Files in This Item:

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

장승기JANG, SUNG KEY
Dept of Life Sciences
Read more

Views & Downloads

Browse