Base-Free Dynamic Kinetic Resolution of Secondary Alcohols with a Ruthenium-Lipase Couple
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SCOPUS
- Title
- Base-Free Dynamic Kinetic Resolution of Secondary Alcohols with a Ruthenium-Lipase Couple
- Authors
- Yun I.; Park J.Y.; Park J.; KIM, MAHN JOO
- Date Issued
- 2019-12
- Publisher
- AMER CHEMICAL SOC
- Abstract
- We report the dynamic kinetic resolution (DKR) of various secondary alcohols by the combination of a ruthenium catalyst and an anionic surfactant-activated lipoprotein lipase. The DKR reactions performed under totally base-free conditions at room temperature provided the products of excellent enantiopurities (91-99% ee or greater) in high yields (92-99%). More importantly, the DKR of alpha-arylallyl alcohols was achieved for the first time with high yields (87-91%).
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/101213
- DOI
- 10.1021/acs.joc.9b02510
- ISSN
- 0022-3263
- Article Type
- Article
- Citation
- JOURNAL OF ORGANIC CHEMISTRY, vol. 84, no. 24, page. 16293 - 16298, 2019-12
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