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Cited 17 time in webofscience Cited 17 time in scopus
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Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii SCIE SCOPUS

Title
Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii
Authors
Marion, Chad R.Lee, JaewookSharma, LokeshPark, Kyong-SuLee, ChangjinLiu, WeiLiu, PeiFeng, JingjingGho, Yong SongDela Cruz, Charles S.
Date Issued
2019-09
Publisher
AMER SOC MICROBIOLOGY
Abstract
Pneumonia due to Gram-negative bacteria is associated with high mortality. Acinetobacter baumannii is a Gram-negative bacterium that is associated with hospital-acquired and ventilator-associated pneumonia. Bacteria have been described to release outer membrane vesicles (OMVs) that are capable of mediating systemic inflammation. The mechanism by which A. baumannii OMVs mediate inflammation is not fully defined. We sought to investigate the roles that Toll-like receptors (TLRs) play in A. baumannii OMV-mediated pulmonary inflammation. We isolated OMVs from A. baumannii cultures and intranasally introduced the OMVs into mice. Intranasal introduction of A. baumannii OMVs mediated pulmonary inflammation, which is associated with neutrophil recruitment and weight loss. In addition, A. baumannii OMVs increased the release of several chemokines and cytokines in the mouse lungs. The proinflammatory responses were partially inhibited in TLR2- and TLR4-deficient mice compared to those of wild-type mice. This study highlights the important roles of TLRs in A. baumannii OMV-induced pulmonary inflammation in vivo.
URI
https://oasis.postech.ac.kr/handle/2014.oak/100444
DOI
10.1128/IAI.00243-19
ISSN
0019-9567
Article Type
Article
Citation
INFECTION AND IMMUNITY, vol. 87, no. 9, 2019-09
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고용송GHO, YONG SONG
Dept of Life Sciences
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