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Cited 32 time in webofscience Cited 35 time in scopus
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A numbering-up metal microreactor for the high-throughput production of a commercial drug by copper catalysis SCIE SCOPUS

Title
A numbering-up metal microreactor for the high-throughput production of a commercial drug by copper catalysis
Authors
Ahn, Gwang-NohYu, TaejongLee, Hyune-JeaGyak, Ki-WonKang, Ji-HoYou, DonghyunKim, Dong-Pyo
Date Issued
2019-10
Publisher
ROYAL SOC CHEMISTRY
Abstract
Microreactors are emerging as an efficient, sustainable synthetic tool compared to conventional batch reactors. Here, we present a new numbering-up metal microreactor by integrating a flow distributor and a copper catalytic module for high productivity of a commercial synthetic drug. A flow distributor and an embedded baffle disc were manufactured by CNC machining and 3D printing of stainless steel (S/S), respectively, whereas a catalytic reaction module was composed of 25 copper coiled capillaries configured in parallel. Eventually, the numbering-up microreactor system assembled with functional modules showed uniform flow distribution and high mixing efficiency regardless of clogging, and achieved high-throughput synthesis of the drug "rufinamide", an anticonvulsant medicine, via a Cu(i)-catalyzed azide-alkyne cycloaddition reaction under optimized conditions.
URI
https://oasis.postech.ac.kr/handle/2014.oak/100218
DOI
10.1039/c9lc00764d
ISSN
1473-0197
Article Type
Article
Citation
LAB ON A CHIP, vol. 19, no. 20, page. 3535 - 3542, 2019-10
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유동현YOU, DONGHYUN
Dept of Mechanical Enginrg
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