Melatonin inhibits nicotinic acetylcholine receptor functions in bovine chromaffin cells
KCI
- Title
- Melatonin inhibits nicotinic acetylcholine receptor functions in bovine chromaffin cells
- Authors
- 조수현; 이승현; 김경태; 최세영
- Date Issued
- 2019-06
- Publisher
- 대한구강생물학회
- Abstract
- Melatonin is a neurotransmitter that modulates various physiological phenomena including regulation and maintenance of the circadian rhythm. Nicotinic acetylcholine receptors (nAChRs) play an important role in oral functions including orofacial muscle contraction, salivary secretion, and tooth development. However, knowledge regarding physiological crosstalk between melatonin and nAChRs is limited. In the present study, the melatonin-mediated modulation of nAChR functions using bovine adrenal chromaffin cells, a representative model for the study of nAChRs, was investigated. Melatonin inhibited the nicotinic agonist dimethylphenylpiperazinium (DMPP) iodide-induced cytosolic free Ca 2+ concentration ([Ca 2+ ] i ) increase and norepinephrine secretion in a concentration-dependent manner. The inhibitory effect of melatonin on the DMPP-induced [Ca 2+ ] i increase was observed when the melatonin treatment was performed simultaneously with DMPP. The results indicate that melatonin inhibits nAChR functions in both peripheral and central nervous systems.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/100145
- ISSN
- 1226-7155
- Article Type
- Article
- Citation
- International Journal of Oral Biology, vol. 44, no. 2, page. 50 - 54, 2019-06
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- There are no files associated with this item.
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