DC Field | Value | Language |
---|---|---|
dc.contributor.author | Beack, S. | - |
dc.contributor.author | Cho, M. | - |
dc.contributor.author | Kim, Y.-E. | - |
dc.contributor.author | Ahn, G.-O. | - |
dc.contributor.author | Hahn, S.K. | - |
dc.date.accessioned | 2018-06-15T05:38:45Z | - |
dc.date.available | 2018-06-15T05:38:45Z | - |
dc.date.created | 2017-12-21 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50692 | - |
dc.description.abstract | Colon cancer is one of the most common death-related cancers in the world. For treating colon cancer, it is crucial to detect and remove malignant lesions early. Here, we developed hyaluronate (HA)-peanut agglutinin (PNA) conjugates for the bioimaging of colon cancer. The HA-PNA conjugates were successfully synthesized by the coupling reaction between aldehyde-modified HA and the N-terminal amine group of PNA. For diagnostic imaging, rhodamine B (RhoB) was chemically conjugated onto PNA in HA-PNA conjugates. After intraluminal injection of HA-PNA-RhoB conjugates into tumor-bearing mice, small-sized colon cancers could be effectively visualized by ex vivo imaging with an in vivo imaging system (IVIS) and a two-photon microscope. With these results taken together, we could confirm the feasibility of HA-PNA-RhoB conjugates as a bioimaging agent for detecting colon cancers. ? 2017 American Chemical Society. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | BIOCONJUGATE CHEMISTRY | - |
dc.subject | aldehyde | - |
dc.subject | amine | - |
dc.subject | contrast medium | - |
dc.subject | hyaluronic acid | - |
dc.subject | peanut agglutinin | - |
dc.subject | rhodamine B | - |
dc.subject | dextran sulfate | - |
dc.subject | hyaluronic acid | - |
dc.subject | peanut agglutinin | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | Article | - |
dc.subject | bioimaging | - |
dc.subject | cancer diagnosis | - |
dc.subject | chemical reaction | - |
dc.subject | chemical structure | - |
dc.subject | colon cancer | - |
dc.subject | conjugate | - |
dc.subject | cytotoxicity test | - |
dc.subject | diagnostic imaging | - |
dc.subject | fluorescence microscopy | - |
dc.subject | gel permeation chromatography | - |
dc.subject | HCT 116 cell line | - |
dc.subject | human | - |
dc.subject | human cell | - |
dc.subject | human cell culture | - |
dc.subject | in vitro study | - |
dc.subject | intraluminal drug administration | - |
dc.subject | mouse | - |
dc.subject | nonhuman | - |
dc.subject | polyacrylamide gel electrophoresis | - |
dc.subject | synthesis | - |
dc.subject | animal | - |
dc.subject | C57BL mouse | - |
dc.subject | cell proliferation | - |
dc.subject | chemically induced | - |
dc.subject | chemistry | - |
dc.subject | colon tumor | - |
dc.subject | drug effects | - |
dc.subject | drug screening | - |
dc.subject | fluorescence microscopy | - |
dc.subject | male | - |
dc.subject | metabolism | - |
dc.subject | pathology | - |
dc.subject | procedures | - |
dc.subject | tissue distribution | - |
dc.subject | tumor cell culture | - |
dc.subject | Animals | - |
dc.subject | Cell Proliferation | - |
dc.subject | Colonic Neoplasms | - |
dc.subject | Dextran Sulfate | - |
dc.subject | Humans | - |
dc.subject | Hyaluronic Acid | - |
dc.subject | Male | - |
dc.subject | Mice | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Microscopy, Fluorescence | - |
dc.subject | Peanut Agglutinin | - |
dc.subject | Tissue Distribution | - |
dc.subject | Tumor Cells, Cultured | - |
dc.subject | Xenograft Model Antitumor Assays | - |
dc.title | Hyaluronate-Peanut Agglutinin Conjugates for Target-Specific Bioimaging of Colon Cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.bioconjchem.7b00126 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCONJUGATE CHEMISTRY, v.28, no.5, pp.1434 - 1442 | - |
dc.identifier.wosid | 000401782000012 | - |
dc.date.tcdate | 2018-03-23 | - |
dc.citation.endPage | 1442 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1434 | - |
dc.citation.title | BIOCONJUGATE CHEMISTRY | - |
dc.citation.volume | 28 | - |
dc.contributor.affiliatedAuthor | Ahn, G.-O. | - |
dc.contributor.affiliatedAuthor | Hahn, S.K. | - |
dc.identifier.scopusid | 2-s2.0-85019641639 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | THERANOSTIC NANOPARTICLES | - |
dc.subject.keywordPlus | SKIN-CANCER | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ENDOSCOPY | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | COLITIS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
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