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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 류혜국 | - |
| dc.contributor.author | JI, YOUNG SEO | - |
| dc.contributor.author | Eunju Lee | - |
| dc.contributor.author | 김은아 | - |
| dc.contributor.author | YOUNGSEOB, JUNG | - |
| dc.contributor.author | KIM, HYOJIN | - |
| dc.contributor.author | EUNJI, OH | - |
| dc.contributor.author | Do-Yeon Kim | - |
| dc.contributor.author | KIM, KYONG TAI | - |
| dc.date.accessioned | 2018-05-11T00:28:27Z | - |
| dc.date.available | 2018-05-11T00:28:27Z | - |
| dc.date.created | 2018-03-02 | - |
| dc.date.issued | 2017-11-14 | - |
| dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/42740 | - |
| dc.description.abstract | spatiotemporallocalizationinordertocarryouttheircriticalfunctions.ThemRNAtranscriptforthesynapticprotein,Activity-regulatedcytoskeleton-associatedprotein(Arc,alsoknownasArg3.1),containstwoconserved3’untranslatedregion(UTR)introns,andconsequently,wasproposedanaturaltargetfornonsense-mediatedmRNAdecay(NMD). ThismechanismwasthoughttofunctionasacriticalbrakeonArcproteinsynthesis,allowingprecisecontrolofgeneexpression.TheRNAhelicaseUpf1isamajorcomponentoftheNMDmachinery,however,aspecificroleforthisproteinintheregulationofArcgeneexpressionremainsunclear.Here,wedemonstratethatUpf1functionsatthetranscriptionalandtranslationalleveltopromotealowbasallevelofArcgeneexpression.Specifically, Upf1suppressesArctranscriptionbyenhancingdestabilizationofmRNAsencodingvarioustranscriptionfactors.Upf1alsobindstotheArc3’UTR,resultingintranslationalsuppression.Surprisingly,however,theArctranscriptescapesfromUpf1-mediatedNMDbybindingtoAgo2/miRISC,whichblocksNMDandfurthersuppressesArcmRNAtranslation.Finally,weshowthatsustainedArcexpressionresultingfromreducedlevelsofUpf1contributestoCofilinhyperphosphorylationandabnormalneuronaloutgrowth. Collectively,thesedatarevealanewparadigmforArcgeneregulationandsuggestthatmultiplelevelsofUpf1-mediatedinhibitionmayallowneuronstomorerapidlyandeffectivelyrespondtochangesinneuronalactivity. | - |
| dc.publisher | SFN | - |
| dc.relation.isPartOf | Society of Neuroscience Annual Meeting 2017 | - |
| dc.relation.isPartOf | Neuroscience 2017 TUESDAY scientific session listing:438-626 | - |
| dc.title | Upf1 contributes to Arc/Arg3.1gene expression | - |
| dc.type | Conference | - |
| dc.type.rims | CONF | - |
| dc.identifier.bibliographicCitation | Society of Neuroscience Annual Meeting 2017 | - |
| dc.citation.conferenceDate | 2017-11-11 | - |
| dc.citation.conferencePlace | US | - |
| dc.citation.title | Society of Neuroscience Annual Meeting 2017 | - |
| dc.contributor.affiliatedAuthor | 류혜국 | - |
| dc.contributor.affiliatedAuthor | JI, YOUNG SEO | - |
| dc.contributor.affiliatedAuthor | 김은아 | - |
| dc.contributor.affiliatedAuthor | YOUNGSEOB, JUNG | - |
| dc.contributor.affiliatedAuthor | KIM, HYOJIN | - |
| dc.contributor.affiliatedAuthor | EUNJI, OH | - |
| dc.contributor.affiliatedAuthor | KIM, KYONG TAI | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalClass | 1 | - |
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- 김경태KIM, KYONG TAI
- Dept of Life Sciences