DC Field | Value | Language |
---|---|---|
dc.contributor.author | KIM, WON JONG | - |
dc.contributor.author | HYEONGMOK, PARK | - |
dc.contributor.author | Kim, Jinhwan | - |
dc.contributor.author | SUNGJIN, JUNG | - |
dc.date.accessioned | 2018-05-04T02:33:50Z | - |
dc.date.available | 2018-05-04T02:33:50Z | - |
dc.date.created | 2018-03-05 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/41189 | - |
dc.description.abstract | In the present study, the design, construction, and operation of a functional DNA-decorated dynamic gold (Au) nanomachine as a therapeutic agent for triple combinatorial anti-cancer therapy are revealed. Taking advantage of the intrinsic optical properties of Au nanoparticles, which depend on their size, a cytosine rich i-motif sequence is employed for intracellular pH-sensitive duplex dissociation and subsequent aggregation of the DNA-Au nanomachine, enabling anticancer drug release and photothermal ablation upon irradiation with infrared light. Moreover, another functional DNA sequence, a G-quadruplex, is exploited for the stable loading and intracellular delivery of a photosensitizer to achieve effective photodynamic therapy under red light illumination. The G-quadruplex-assisted enhanced reactive oxygen species generation, pH-responsive dynamic aggregation behavior, consequent drug release, and the photothermal effect are investigated. Furthermore, the combinatorial chemo, photodynamic, and photothermal therapeutic effects of the functional DNA-decorated Au nanomachines are evaluated in vitro and in vivo using a triple negative breast cancer model. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | ADVANCED FUNCTIONAL MATERIALS | - |
dc.title | DNA-Au Nanomachine Equipped with i-Motif and G-Quadruplex for Triple Combinatorial Anti-Tumor Therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/adfm.201705416 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ADVANCED FUNCTIONAL MATERIALS, v.28, no.5 | - |
dc.identifier.wosid | 000423512300016 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.number | 5 | - |
dc.citation.title | ADVANCED FUNCTIONAL MATERIALS | - |
dc.citation.volume | 28 | - |
dc.contributor.affiliatedAuthor | KIM, WON JONG | - |
dc.contributor.affiliatedAuthor | HYEONGMOK, PARK | - |
dc.contributor.affiliatedAuthor | SUNGJIN, JUNG | - |
dc.identifier.scopusid | 2-s2.0-85041058420 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 5 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | ARTICLE | - |
dc.subject.keywordPlus | STIMULI-RESPONSIVE MATERIALS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | SYNERGISTIC THERAPY | - |
dc.subject.keywordPlus | SIRNA DELIVERY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordAuthor | combination therapy | - |
dc.subject.keywordAuthor | DNA nanotechnology | - |
dc.subject.keywordAuthor | gold nanomachines | - |
dc.subject.keywordAuthor | G-quadruplexes | - |
dc.subject.keywordAuthor | i-motif | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.