DC Field | Value | Language |
---|---|---|
dc.contributor.author | YUN, EUN JIN | - |
dc.contributor.author | Chen, Wei | - |
dc.contributor.author | Zhou, Jiancheng | - |
dc.contributor.author | Wu, Kaijie | - |
dc.contributor.author | Huang, Jun | - |
dc.contributor.author | Ding, Ye | - |
dc.contributor.author | Wang, Bin | - |
dc.contributor.author | Ding, Chunyong | - |
dc.contributor.author | Hernandez, Elizabeth | - |
dc.contributor.author | Santoyo, John | - |
dc.contributor.author | Chen, Haiying | - |
dc.contributor.author | Lin, Ho | - |
dc.contributor.author | Sagalowsky, Arthur | - |
dc.contributor.author | He, Dalin | - |
dc.contributor.author | Zhou, Jia | - |
dc.contributor.author | Hsieh, Jer-Tsong | - |
dc.date.accessioned | 2018-01-04T11:17:09Z | - |
dc.date.available | 2018-01-04T11:17:09Z | - |
dc.date.created | 2017-11-13 | - |
dc.date.issued | 2016-08-30 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/39244 | - |
dc.description.abstract | Conventional chemotherapy is commonly used for advanced stages of transitional cell carcinoma (TCC) with modest success and high morbidity; however, TCC eventually develops resistance. Muscle invasive bladder cancer (MIBC) is recognized as a lethal disease due to its poor response to traditional chemotherapy. Numerous studies have implicated beta-catenin, a critical effector in Wnt-mediated pathway associated with epithelial-mesenchymal transition and cancer stem cell, is involved in TCC progression, and furthermore closely associated with chemo-resistance. In this study, we discovered a novel natural product analogue CYD 6-17 that has a potent inhibitory effect on TCC cells exhibiting drug resistance to various chemotherapeutics, with an IC50 at nM range. Delivery of CYD 6-17 significantly inhibited the tumor growth using xenograft model but without detectable side effects. Mechanistically, it targeted beta-catenin gene transcription by decreasing the binding of XBP1 to the promoter region, which appeared to be a new regulatory mechanism for beta-catenin gene expression. Clinically, XBP1 expression correlated with the poor overall survival of patients. Overall, this study unveils unique mechanism of beta-catenin gene regulation in advanced TCC and also offers a potential rational therapeutic regimen to MIBC. | - |
dc.language | English | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.relation.isPartOf | Oncotarget | - |
dc.subject | UROTHELIAL CARCINOMAS | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | IN-VITRO | - |
dc.subject | CHEMORESISTANCE | - |
dc.subject | WNT | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTEIN | - |
dc.subject | CELLS | - |
dc.subject | GENE | - |
dc.subject | THERAPY | - |
dc.title | Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues | - |
dc.type | Article | - |
dc.identifier.doi | 10.18632/oncotarget.10863 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Oncotarget, v.7, no.35, pp.56842 - 56854 | - |
dc.identifier.wosid | 000386911600072 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 56854 | - |
dc.citation.number | 35 | - |
dc.citation.startPage | 56842 | - |
dc.citation.title | Oncotarget | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | YUN, EUN JIN | - |
dc.identifier.scopusid | 2-s2.0-84984878615 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 8 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | WNT | - |
dc.subject.keywordPlus | CHEMORESISTANCE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordAuthor | Oridonin | - |
dc.subject.keywordAuthor | Wnt pathway | - |
dc.subject.keywordAuthor | beta-catenin | - |
dc.subject.keywordAuthor | XBP1 | - |
dc.subject.keywordAuthor | transitional cell carcinoma | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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