DC Field | Value | Language |
---|---|---|
dc.contributor.author | DOH, JUNSANG | - |
dc.contributor.author | Tae-Don Kim | - |
dc.contributor.author | Hong-Ryul Jung | - |
dc.contributor.author | Sang-Hwan Se | - |
dc.contributor.author | Se-Chan Oh | - |
dc.contributor.author | Youngho Ban | - |
dc.contributor.author | Xiaoxia Tan | - |
dc.contributor.author | Jung Min Kim | - |
dc.contributor.author | Sang Hyun Lee | - |
dc.contributor.author | Duk-Su Koh | - |
dc.contributor.author | Haiyoung Jung | - |
dc.contributor.author | Young-Jun Park | - |
dc.contributor.author | Suk Ran Yoon | - |
dc.contributor.author | Inpyo Choi | - |
dc.contributor.author | Sang-Jun Ha | - |
dc.contributor.author | Philip D.Greenberg | - |
dc.date.accessioned | 2018-01-04T06:50:40Z | - |
dc.date.available | 2018-01-04T06:50:40Z | - |
dc.date.created | 2017-11-21 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/39084 | - |
dc.description.abstract | Regulation of intracellular Ca2+ signaling is a major determinant of CD8+ T cell responsiveness, but the mechanisms underlying this regulation of Ca2+ levels, especially in naïve CD8+ T cells, are not fully defined. Here, we showed that microRNA-150 (miR-150) controls intracellular Ca2+ levels in naïve CD8+ T cells required for activation by suppressing TMEM20, a negative regulator of Ca2+ extrusion. miR-150 deficiency increased TMEM20 expression, which resulted in increased intracellular Ca2+ levels in naïve CD8+ T cells. The subsequent increase in Ca2+ levels induced expression of anergy-inducing genes, such as Cbl-b, Egr2, and p27, through activation of NFAT1, as well as reduced cell proliferation, cytokine production, and the antitumor activity of CD8+ T cells upon antigenic stimulation. The anergy-promoting molecular milieu and function induced by miR-150 deficiency were rescued by reinstatement of miR-150. Additionally, knockdown of TMEM20 in miR-150-deficient naïve CD8+ T cells reduced intracellular Ca2+ levels. Our findings revealed that miR-150 play essential roles in controlling intracellular Ca2+ level and activation in naïve CD8+ T cells, which suggest a mechanism to overcome anergy induction by the regulation of intracellular Ca2+ levels | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Scientific Reports | - |
dc.title | MicroRNA-150 modulates intracellular Ca2+ levels in naïve CD8+ T cells by targeting TMEM20 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-017-02697-x | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.7, pp.2623 | - |
dc.identifier.wosid | 000402508400004 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.startPage | 2623 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | DOH, JUNSANG | - |
dc.identifier.scopusid | 2-s2.0-85020214170 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 5 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | ARTICLE | - |
dc.subject.keywordPlus | MIR-150 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | ANERGY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | STIM1 | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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