DC Field | Value | Language |
---|---|---|
dc.contributor.author | Woo, SJ | - |
dc.contributor.author | Park, S | - |
dc.contributor.author | Jeong, JE | - |
dc.contributor.author | Hong, Y | - |
dc.contributor.author | Ku, M | - |
dc.contributor.author | Kim, BY | - |
dc.contributor.author | Jang, IH | - |
dc.contributor.author | Heo, SC | - |
dc.contributor.author | Wang, T | - |
dc.contributor.author | Kim, KH | - |
dc.contributor.author | Yang, J | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Woo, HY | - |
dc.date.accessioned | 2017-07-19T12:50:44Z | - |
dc.date.available | 2017-07-19T12:50:44Z | - |
dc.date.created | 2016-11-16 | - |
dc.date.issued | 2016-06-29 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/36535 | - |
dc.description.abstract | Near-infrared (NIR) fluorophores attract increasing attention as a molecular marker (or probe) for in vivo and in vitro biological fluorescence imaging. Three types of new NIR fluorescent conjugated oligoelectrolytes (COEs: Q-FITBTTFI, Q-FIBBTFI, and Q-FITBBTTFI) are synthesized with quaternized ammonium ionic groups in their side-chains for water solubility. The emission wavelength is modulated in the range 600-1300 nm, by adjusting the intramolecular charge transfer in the molecular backbone based on the electron-rich fluorene (and/or thiophene) and electron-deficient benzo[2,1,3]thiadiazole (or benzo[1,2-c:4,5-c']bis[1,2,5]thiadiazole) moieties. The COEs show a remarkably larger Stokes shift (147-276 nm) compared to commercial rhodamine and cyanine dyes in water, avoiding self-quenching and interference from the excitation backscattered light. The photoluminescence (PL) quantum efficiency is improved substantially by up to 27.8% in water by fabricating a vesicular complex, COE/v, with a block ionomer, poly[(ethylene oxide)-block-(sodium 2-acrylamido-2-methyl-1-propanesulfonate)]. In vitro cellular uptake images with the COEs are obtained with good biocompatibility by confocal single-photon and two-photon microscopy. The ex vivo and in vivo images of a mouse xenograft model treated with the QFIBBTFliv exhibit a substantially stronger fluorescence signal at the tumor site than at the other organs, highlighting the potential of the COE/v as an NIR fluorescent imaging agent for the diagnosis of cancer. | - |
dc.language | English | - |
dc.publisher | ACS | - |
dc.relation.isPartOf | ACS Appl Mater Interfaces | - |
dc.title | Synthesis and Characterization of Water-Soluble Conjugated Oligoelectrolytes for Near-Infrared Fluorescence Biological Imaging | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/ACSAMI.6B04276 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACS Appl Mater Interfaces, v.8, no.25, pp.15937 - 15947 | - |
dc.identifier.wosid | 000378984800009 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 15947 | - |
dc.citation.number | 25 | - |
dc.citation.startPage | 15937 | - |
dc.citation.title | ACS Appl Mater Interfaces | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Kim, KH | - |
dc.identifier.scopusid | 2-s2.0-84976877727 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 8 | - |
dc.description.scptc | 6 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | POLYHEDRAL OLIGOMERIC SILSESQUIOXANE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MACROMOLECULAR THERAPEUTICS | - |
dc.subject.keywordPlus | CANCER-CHEMOTHERAPY | - |
dc.subject.keywordPlus | SI-RHODAMINE | - |
dc.subject.keywordPlus | FAR-RED | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | MICROSCOPY | - |
dc.subject.keywordPlus | DYES | - |
dc.subject.keywordPlus | POLYELECTROLYTE | - |
dc.subject.keywordAuthor | conjugated oligoelectrolytes | - |
dc.subject.keywordAuthor | near-infrared fluorophores | - |
dc.subject.keywordAuthor | vesicle | - |
dc.subject.keywordAuthor | Stokes shift | - |
dc.subject.keywordAuthor | bioimaging | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
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