DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, US | - |
dc.contributor.author | Choi, JP | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Kim, YK | - |
dc.date.accessioned | 2017-07-19T12:24:27Z | - |
dc.date.available | 2017-07-19T12:24:27Z | - |
dc.date.created | 2016-01-13 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/35781 | - |
dc.description.abstract | Atherosclerosis is a chronic progressive inflammatory disorder and the leading cause of cardiovascular mortality. Here we assessed the dynamic changes of T-cell-derived cytokines, such as inteferon (IFN)-gamma, interleukin (IL)-17 and IL-4, during the progression of atherosclerosis in apolipoprotein E-null (ApoE(-/-)) mice, to understand the role of immune responses in different stages of atherosclerosis. Male ApoE(-/-) mice were fed a high-fat, western-type diet (WD: 21% lipid, 1.5% cholesterol) after 5 weeks of age and were compared with C57BL/6 wild-type control mice fed a standard chow diet. Atherosclerotic lesions appeared in the aortic sinus of ApoE(-/-) mice 4 weeks after WD and the lesions progressed and occupied > 50% of the total sinus area 16 weeks after WD. Aortic IL-17 mRNA and protein expression started to increase in ApoE(-/-) mice after 4 weeks on the WD and peaked at around 8-12 weeks on the WD. In terms of systemic expression of T-cell-derived cytokines, IL-17 production from splenocytes after anti-CD3/CD28 stimuli increased from 4 weeks on the WD, peaked at 12 weeks and returned to control levels at 16 weeks. The production of IFN-gamma and IL-4 (Th1 and Th2 cytokines, respectively) from splenocytes was delayed compared with IL-17. Taken together, the present data indicate that Th17 cell response may be involved at an early stage in the development of atherosclerosis. | - |
dc.language | English | - |
dc.publisher | 생화학분자생물학회 | - |
dc.relation.isPartOf | Experimental and Molecular Medicine | - |
dc.title | The enhanced expression of IL-17-secreting T cells during the early progression of atherosclerosis in ApoE-deficient mice fed on a western-type diet | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/EMM.2015.19 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Experimental and Molecular Medicine, v.47 | - |
dc.identifier.wosid | 000358594500003 | - |
dc.date.tcdate | 2019-03-01 | - |
dc.citation.title | Experimental and Molecular Medicine | - |
dc.citation.volume | 47 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-84942092009 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 9 | - |
dc.description.scptc | 11 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TH17 CELLS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | LINEAGE | - |
dc.subject.keywordPlus | DEVELOP | - |
dc.subject.keywordPlus | PLAQUE | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | GAMMA | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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