DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, C | - |
dc.contributor.author | Lee, OC | - |
dc.contributor.author | Kim, JY | - |
dc.contributor.author | Sung, W | - |
dc.contributor.author | Lee, NK | - |
dc.date.accessioned | 2017-07-19T11:39:50Z | - |
dc.date.available | 2017-07-19T11:39:50Z | - |
dc.date.created | 2015-10-13 | - |
dc.date.issued | 2015-07-27 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/35279 | - |
dc.description.abstract | Bending with high curvature is one of the major mechanical properties of double-stranded DNA (dsDNA) that is essential for its biological functions. The emergence of a kink arising from local melting in the middle of dsDNA has been suggested as a mechanism of releasing the energy cost of bending. Herein, we report that strong bending induces two types of short dsDNA deformations, induced by two types of local melting, namely, a kink in the middle and forks at the ends, which we demonstrate using D-shaped DNA nanostructures. The two types of deformed dsDNA structures dynamically interconvert on a millisecond timescale. The transition from a fork to a kink is dominated by entropic contribution (anti-Arrhenius behavior), while the transition from a kink to a fork is dominated by enthalpic contributions. The presence of mismatches in dsDNA accelerates kink formation, and the transition from a kink to a fork is removed when the mismatch size is three base pairs. | - |
dc.language | English | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.relation.isPartOf | Angewandte Chemie - International Edition | - |
dc.title | Dynamic Release of Bending Stress in Short dsDNA by Formation of a Kink and Forks | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ANIE.201502055 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Angewandte Chemie - International Edition, v.54, no.31, pp.8943 - 8947 | - |
dc.identifier.wosid | 000358501500008 | - |
dc.date.tcdate | 2019-03-01 | - |
dc.citation.endPage | 8947 | - |
dc.citation.number | 31 | - |
dc.citation.startPage | 8943 | - |
dc.citation.title | Angewandte Chemie - International Edition | - |
dc.citation.volume | 54 | - |
dc.contributor.affiliatedAuthor | Sung, W | - |
dc.contributor.affiliatedAuthor | Lee, NK | - |
dc.identifier.scopusid | 2-s2.0-84937514559 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 5 | - |
dc.description.scptc | 7 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SINGLE-MOLECULE | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | LENGTH | - |
dc.subject.keywordPlus | FLEXIBILITY | - |
dc.subject.keywordPlus | CURVATURE | - |
dc.subject.keywordPlus | BUBBLES | - |
dc.subject.keywordPlus | FORCES | - |
dc.subject.keywordAuthor | bending | - |
dc.subject.keywordAuthor | DNA structures | - |
dc.subject.keywordAuthor | FRET | - |
dc.subject.keywordAuthor | kinks | - |
dc.subject.keywordAuthor | mismatched sequences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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