DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, CH | - |
dc.contributor.author | Lee, MS | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Je, YT | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Lee, T | - |
dc.date.accessioned | 2016-04-01T08:47:10Z | - |
dc.date.available | 2016-04-01T08:47:10Z | - |
dc.date.created | 2009-07-30 | - |
dc.date.issued | 2009-02 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.other | 2009-OAK-0000017060 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/28762 | - |
dc.description.abstract | A novel synthetic hexapeptide (SFKLRY-NH2) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). The peptide induced proliferation, migration, and capillary-like tube formation in primary cultured HUVECs, and augmented vessel sprouting ex vivo while attenuated by the treatment with per-tussis toxin (PTX) or U73122 (PLC-inhibitor) suggesting the influence of PTX-sensitive G-proteins and PLC. In addition, SFKLRY-NH2 up-regulated the expression of VEGF-A in HUVECs and the neutralizing antibody against VEGF suppressed SFKLRY-NH2-induced tube formation activity. Taken together, these results suggest that SFKLRY-NH2 may induce blood vessel formation by PTX-sensitive G protein-coupled receptor-PLC-Ca2+ signaling cascade leading into VEGF-A expression in HUVECs. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | PEPTIDES | - |
dc.subject | SFKLRY-NH(2) | - |
dc.subject | GPCR | - |
dc.subject | Calcium | - |
dc.subject | VEGF | - |
dc.subject | HUVECs | - |
dc.subject | Angiogenesis | - |
dc.subject | PS-SPCL | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | INOSITOL TRISPHOSPHATE | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | HYDROLYSIS | - |
dc.subject | ACTIVATION | - |
dc.subject | MASTOPARAN | - |
dc.subject | CALCIUM | - |
dc.subject | KINASE | - |
dc.subject | MECHANISMS | - |
dc.subject | GENERATION | - |
dc.title | Identification of novel synthetic peptide showing angiogenic activity in human endothelial cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/j.peptides.2008.10.003 | - |
dc.author.google | Lee, CH | - |
dc.author.google | Lee, MS | - |
dc.author.google | Kim, SJ | - |
dc.author.google | Je, YT | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Lee, T | - |
dc.relation.volume | 30 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 409 | - |
dc.relation.lastpage | 418 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | PEPTIDES | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PEPTIDES, v.30, no.2, pp.409 - 418 | - |
dc.identifier.wosid | 000263447700027 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 418 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 409 | - |
dc.citation.title | PEPTIDES | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-58149479560 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | INOSITOL TRISPHOSPHATE | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | HYDROLYSIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MASTOPARAN | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordAuthor | SFKLRY-NH2 | - |
dc.subject.keywordAuthor | GPCR | - |
dc.subject.keywordAuthor | Calcium | - |
dc.subject.keywordAuthor | VEGF | - |
dc.subject.keywordAuthor | HUVECs | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | PS-SPCL | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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