DC Field | Value | Language |
---|---|---|
dc.contributor.author | Geun Ho Im | - |
dc.contributor.author | Soo Min Kim | - |
dc.contributor.author | Dong-Gyu Lee | - |
dc.contributor.author | Won Jae Lee | - |
dc.contributor.author | Jung Hee Lee | - |
dc.contributor.author | Lee, IS | - |
dc.date.accessioned | 2016-04-01T08:12:29Z | - |
dc.date.available | 2016-04-01T08:12:29Z | - |
dc.date.created | 2013-02-27 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.other | 2013-OAK-0000026585 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27468 | - |
dc.description.abstract | To investigate whether it is possible to develop a dual magnetic resonance (MR) contrast agent, Fe3O4/MnO hybrid nanocrystals were modified to integrate the T-1 and T-2 contrast-enhancing abilities of each compound, and their characteristics as MR contrast agents were investigated. In vitro and in vivo investigations revealed that the Fe3O4/MnO dumbbell-shaped nanocrystal exerted a negative T-2 contrast effect in its intact form and also gave rise to a positive contrast effect in T-1-weighted MR imaging by releasing Mn2+ ions in a low pH environment. This induced organ-specific contrast enhancement for both T-1- and T-2-weighted in vivo MR imaging. The usefulness of the Fe3O4/MnO hybrid nanocrystals as dual contrast agents was evaluated by in vivo MR imaging of an orthotopic xenograft model of human hepatocellular carcinoma (HCC). After injection of the Fe3O4/MnO hybrid nanocrystals, dual contrast-enhanced MR images that synergistically combined the T-2 and T-1 contrast effects from the Fe3O4 grain and released Mn2+ ions were obtained by a single acquisition of MR imaging. This facilitated the detection of HCC with a high degree of conspicuity that could not be achieved with any single contrast agent. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.title | Fe3O4/MnO hybrid nanocrystals as a dual contrast agent for both T-1- and T-2-weighted liver MRI | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1016/J.BIOMATERIALS.2012.11.054 | - |
dc.author.google | Im G.H., Kim S.M., Lee D.-G., Lee W.J., Lee J.H., Lee I.S. | - |
dc.relation.volume | 34 | - |
dc.relation.issue | 8 | - |
dc.relation.startpage | 2069 | - |
dc.relation.lastpage | 2076 | - |
dc.contributor.id | 10179922 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.34, no.8, pp.2069 - 2076 | - |
dc.identifier.wosid | 000315003500020 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 2076 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2069 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 34 | - |
dc.contributor.affiliatedAuthor | Dong-Gyu Lee | - |
dc.contributor.affiliatedAuthor | Lee, IS | - |
dc.identifier.scopusid | 2-s2.0-84871522844 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 55 | - |
dc.description.scptc | 50 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | IRON-OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE | - |
dc.subject.keywordPlus | MANGAFODIPIR TRISODIUM | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | MNO NANOPARTICLES | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | RELAXIVITY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Nanoparticle | - |
dc.subject.keywordAuthor | MRI (magnetic resonance imaging) | - |
dc.subject.keywordAuthor | Contrast agent | - |
dc.subject.keywordAuthor | Liver | - |
dc.subject.keywordAuthor | Dual contrast agent | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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