DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, B | - |
dc.contributor.author | Brinkmann, MM | - |
dc.contributor.author | Spooner, E | - |
dc.contributor.author | Lee, CC | - |
dc.contributor.author | Kim, YM | - |
dc.contributor.author | Ploegh, HL | - |
dc.date.accessioned | 2016-04-01T03:05:08Z | - |
dc.date.available | 2016-04-01T03:05:08Z | - |
dc.date.created | 2010-11-24 | - |
dc.date.issued | 2008-12 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.other | 2010-OAK-0000020766 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26233 | - |
dc.description.abstract | Toll-like receptors (TLRs) activate the innate immune system in response to pathogens. Here we show that TLR9 proteolytic cleavage is a prerequisite for TLR9 signaling. Inhibition of lysosomal proteolysis rendered TLR9 inactive. The carboxy-terminal fragment of TLR9 thus generated included a portion of the TLR9 ectodomain, as well as the transmembrane and cytoplasmic domains. This cleavage fragment bound to the TLR9 ligand CpG DNA and, when expressed in Tlr9(-/-) dendritic cells, restored CpG DNA-induced cytokine production. Although cathepsin L generated the requisite TLR9 cleavage products in a cell-free in vitro system, several proteases influenced TLR9 cleavage in intact cells. Lysosomal proteolysis thus contributes to innate immunity by facilitating specific cleavage of TLR9. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE IMMUNOLOGY | - |
dc.subject | ANTIGEN PRESENTATION | - |
dc.subject | PATTERN-RECOGNITION | - |
dc.subject | CATHEPSIN-L | - |
dc.subject | PATHWAY | - |
dc.subject | TLR9 | - |
dc.subject | MICE | - |
dc.subject | DNA | - |
dc.subject | INDUCTION | - |
dc.subject | COMPLEXES | - |
dc.subject | MOLECULE | - |
dc.title | Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1038/NI.1669PG 8 | - |
dc.author.google | Park, B | - |
dc.author.google | Brinkmann, MM | - |
dc.author.google | Spooner, E | - |
dc.author.google | Lee, CC | - |
dc.author.google | Kim, YM | - |
dc.author.google | Ploegh, HL | - |
dc.relation.volume | 9 | - |
dc.relation.issue | 12 | - |
dc.relation.startpage | 1407 | - |
dc.relation.lastpage | 1414 | - |
dc.contributor.id | 10608366 | - |
dc.relation.journal | NATURE IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE IMMUNOLOGY, v.9, no.12, pp.1407 - 1414 | - |
dc.identifier.wosid | 000260888700016 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1414 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1407 | - |
dc.citation.title | NATURE IMMUNOLOGY | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Kim, YM | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 315 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | PATTERN-RECOGNITION | - |
dc.subject.keywordPlus | CATHEPSIN-L | - |
dc.subject.keywordPlus | TLR9 | - |
dc.subject.keywordPlus | MOLECULE | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | LPS | - |
dc.subject.keywordPlus | DNA | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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