DC Field | Value | Language |
---|---|---|
dc.contributor.author | Green, NM | - |
dc.contributor.author | Laws, A | - |
dc.contributor.author | Kiefer, K | - |
dc.contributor.author | Busconi, L | - |
dc.contributor.author | Kim, YM | - |
dc.contributor.author | Brinkmann, MM | - |
dc.contributor.author | Trail, EH | - |
dc.contributor.author | Yasuda, K | - |
dc.contributor.author | Christensen, SR | - |
dc.contributor.author | Shlomchik, MJ | - |
dc.contributor.author | Vogel, S | - |
dc.contributor.author | Connor, JH | - |
dc.contributor.author | Ploegh, H | - |
dc.contributor.author | Eilat, D | - |
dc.contributor.author | Rifkin, IR | - |
dc.contributor.author | van Seventer, JM | - |
dc.contributor.author | Marshak-Rothstein, A | - |
dc.date.accessioned | 2016-04-01T03:05:01Z | - |
dc.date.available | 2016-04-01T03:05:01Z | - |
dc.date.created | 2010-11-24 | - |
dc.date.issued | 2009-08-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2010-OAK-0000020769 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26230 | - |
dc.description.abstract | Type I IFNs play an important, yet poorly characterized, role in systemic lupus erythematosus. To better understand the interplay between type I IFNs and the activation of autoreactive B cells, we evaluated the effect of type I IFN receptor (IFNAR) deficiency in murine B cell responses to common TLR ligands. In comparison to wild-type B cells, TLR7-stimulated IFNAR(-/-) B cells proliferated significantly less well and did not up-regulate costimulatory molecules. By contrast, IFNAR1(-/-) B cells did not produce cytokines, but did proliferate and up-regulate activation markers in response to other TLR ligands. These defects were not due to a difference in the distribution of B cell populations or a failure to produce a soluble factor other than a type I IFN. Instead, the compromised response pattern reflected the disruption of an IFN-beta feedback loop and constitutively low expression of TLR7 in the IFNAR1(-/-) B cells. These results highlight subtle differences in the IFN dependence of TLR7 responses compared with other TLR-mediated B cell responses. The Journal of Immunology, 2009, 183: 1569-1576. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | I INTERFERON RECEPTOR | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | PLASMACYTOID DENDRITIC CELLS | - |
dc.subject | MEDIATED ENHANCEMENT | - |
dc.subject | IMMUNE-COMPLEXES | - |
dc.subject | ALPHA PRODUCTION | - |
dc.subject | MICE | - |
dc.subject | ACTIVATION | - |
dc.subject | DISEASE | - |
dc.title | Murine B Cell Response to TLR7 Ligands Depends on an IFN-beta Feedback Loop | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.4049/JIMMUNOL.0803899PG 8 | - |
dc.author.google | Green, NM | - |
dc.author.google | Laws, A | - |
dc.author.google | Kiefer, K | - |
dc.author.google | Busconi, L | - |
dc.author.google | Kim, YM | - |
dc.author.google | Brinkmann, MM | - |
dc.author.google | Trail, EH | - |
dc.author.google | Yasuda, K | - |
dc.author.google | Christensen, SR | - |
dc.author.google | Shlomchik, MJ | - |
dc.author.google | Vogel, S | - |
dc.author.google | Connor, JH | - |
dc.author.google | Ploegh, H | - |
dc.author.google | Eilat, D | - |
dc.author.google | Rifkin, IR | - |
dc.author.google | van Seventer, JM | - |
dc.author.google | Marshak-Rothstein, A | - |
dc.relation.volume | 183 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 1569 | - |
dc.relation.lastpage | 1576 | - |
dc.contributor.id | 10608366 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.183, no.3, pp.1569 - 1576 | - |
dc.identifier.wosid | 000268519500012 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1576 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1569 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 183 | - |
dc.contributor.affiliatedAuthor | Kim, YM | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 69 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | I INTERFERON RECEPTOR | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | PLASMACYTOID DENDRITIC CELLS | - |
dc.subject.keywordPlus | MEDIATED ENHANCEMENT | - |
dc.subject.keywordPlus | IMMUNE-COMPLEXES | - |
dc.subject.keywordPlus | ALPHA PRODUCTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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