DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kong, JH | - |
dc.contributor.author | Oh, EJ | - |
dc.contributor.author | Chae, SY | - |
dc.contributor.author | Lee, KC | - |
dc.contributor.author | Hahn, SK | - |
dc.date.accessioned | 2016-04-01T02:52:02Z | - |
dc.date.available | 2016-04-01T02:52:02Z | - |
dc.date.created | 2010-06-16 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.other | 2010-OAK-0000021360 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25897 | - |
dc.description.abstract | Despite clinical exploitation of exendin 4 for the treatment of type 2 diabetes, the significantly short half-life requiring twice a day injection has limited the wide applications. In this work, a protocol for the synthesis of long acting hyaluronate (HA) - exendin 4 conjugate was successfully developed using Michael addition chemistry between vinyl sulfone modified HA (HA-VS) and thiolated exendin 4. The exendin 4 content could be controlled in the range of 5-30 molecules per single HA chain with a bio-conjugation efficiency higher than 90%. The conjugation of exendin 4 with HA resulted in about 20 times improved in vitro serum stability maintaining the hypoglycemic and gluco-regulatory bioactivities of exendin 4. HA - exendin 4 conjugates showed excellent glucose-lowering capabilities in type 2 db/db mice demonstrating protracted hypoglycemic effect up to 3 days after a single subcutaneous injection. Furthermore, insulin immunohistochemical analysis of islets in db/db mice confirmed the improved insulinotropic activity of HA - exendin 4 conjugates. The HA - exendin 4 conjugates will be investigated further as a twice a week injection dosage form for clinical applications. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.subject | Hyaluronic acid | - |
dc.subject | Exendin-4 | - |
dc.subject | Conjugation | - |
dc.subject | Drug delivery | - |
dc.subject | Type 2 diabetes | - |
dc.subject | ACID HYDROGELS | - |
dc.subject | EXENATIDE EXENDIN-4 | - |
dc.subject | QUANTUM DOTS | - |
dc.subject | PEPTIDE | - |
dc.subject | DEGRADATION | - |
dc.subject | PEGYLATION | - |
dc.subject | CHEMISTRY | - |
dc.subject | RECEPTOR | - |
dc.subject | ANALOGS | - |
dc.subject | WEIGHT | - |
dc.title | Long Acting Hyaluronate-Exendin 4 Conjugate for the Treatment of Type 2 Diabetes | - |
dc.type | Article | - |
dc.contributor.college | 신소재공학과 | - |
dc.identifier.doi | 10.1016/J.BIOMATERIALS.2010.01.091 | - |
dc.author.google | Kong, JH | - |
dc.author.google | Oh, EJ | - |
dc.author.google | Chae, SY | - |
dc.author.google | Lee, KC | - |
dc.author.google | Hahn, SK | - |
dc.relation.volume | 31 | - |
dc.relation.issue | 14 | - |
dc.relation.startpage | 4121 | - |
dc.relation.lastpage | 4128 | - |
dc.contributor.id | 10149037 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.31, no.14, pp.4121 - 4128 | - |
dc.identifier.wosid | 000276541300041 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 4128 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 4121 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 31 | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.identifier.scopusid | 2-s2.0-77649272159 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 38 | - |
dc.description.scptc | 41 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ACID HYDROGELS | - |
dc.subject.keywordPlus | EXENATIDE EXENDIN-4 | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | PEGYLATION | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | WEIGHT | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Exendin-4 | - |
dc.subject.keywordAuthor | Conjugation | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Type 2 diabetes | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.