DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Choi, SJ | - |
dc.contributor.author | Tae, YM | - |
dc.contributor.author | Lee, BJ | - |
dc.contributor.author | Jeon, SG | - |
dc.contributor.author | Oh, SY | - |
dc.contributor.author | Gho, YS | - |
dc.contributor.author | Zhu, Z | - |
dc.contributor.author | Kim, YK | - |
dc.date.accessioned | 2016-04-01T02:41:16Z | - |
dc.date.available | 2016-04-01T02:41:16Z | - |
dc.date.created | 2010-11-24 | - |
dc.date.issued | 2010-11-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2010-OAK-0000021981 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25588 | - |
dc.description.abstract | Vascular endothelial growth factor (VEGF) is a key mediator in the development of airway immune dysfunction to inhaled allergens. However, the exact role of its receptors-mediated signaling is controversial. In this study, we evaluated the role of VEGF receptor (VEGFR)-1- and VEGFR-2-mediated signaling in T cell priming and polarization in the context of inhalation of LPS-containing allergens. A murine asthma model of mixed Th1 and Th17 cell responses was generated using intranasal sensitization with LPS-containing allergens. Pharmacologic intervention was performed during sensitization. In vivo production of VEGF and Th1- and Th17-polarizing cytokines (IL-12p70 and IL-6, respectively) were upregulated by airway exposure to LPS. Pharmacological intervention with a VEGFR-2-neutralizing Ab (anti-Flk1 mAb) abolished the production of IL-6 (but not IL-12p70) and the subsequent development of allergen-specific Th17 cell response. On the other hand, blocking VEGFR-1 signaling with a VEGFR-1 antagonist (anti-Flt1 hexapeptide) did not affect the production of IL-12p70 and IL-6. However, blocking VEGFR-1 signaling resulted in T cell tolerance rather than priming, mainly by inhibiting the maturation of lung dendritic cells, and their migration into lung-draining lymph nodes. These results suggest that T cell priming to LPS-containing allergens depends on VEGFR-1-mediated signaling, and the subsequent Th17 polarization depends on VEGFR-2 signaling. The Journal of Immunology, 2010, 185: 5648-5655. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | DENDRITIC CELL | - |
dc.subject | FACTOR VEGF | - |
dc.subject | EXPERIMENTAL ASTHMA | - |
dc.subject | LYMPH-NODES | - |
dc.subject | EXPRESSION | - |
dc.subject | AIRWAYS | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | MATURATION | - |
dc.subject | MIGRATION | - |
dc.subject | RESPONSES | - |
dc.title | Distinct Roles of Vascular Endothelial Growth Factor Receptor-1-and Receptor-2-Mediated Signaling in T Cell Priming and Th17 Polarization to Lipopolysaccharide-Containing Allergens in the Lung | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/JIMMUNOL.1001713 | - |
dc.author.google | Kim, YS | - |
dc.author.google | Choi, SJ | - |
dc.author.google | Tae, YM | - |
dc.author.google | Lee, BJ | - |
dc.author.google | Jeon, SG | - |
dc.author.google | Oh, SY | - |
dc.author.google | Gho, YS | - |
dc.author.google | Zhu, Z | - |
dc.author.google | Kim, YK | - |
dc.relation.volume | 185 | - |
dc.relation.issue | 9 | - |
dc.relation.startpage | 5648 | - |
dc.relation.lastpage | 5655 | - |
dc.contributor.id | 10103891 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.185, no.9, pp.5648 - 5655 | - |
dc.identifier.wosid | 000283248700079 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 5655 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 5648 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 185 | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.identifier.scopusid | 2-s2.0-78149479629 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 20 | - |
dc.description.scptc | 23 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DENDRITIC CELL | - |
dc.subject.keywordPlus | FACTOR VEGF | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | MEDIATOR | - |
dc.subject.keywordPlus | TYPE-1 | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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