DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, M | - |
dc.contributor.author | Kim, MJ | - |
dc.contributor.author | Ha, S | - |
dc.contributor.author | Park, JB | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-04-01T02:07:47Z | - |
dc.date.available | 2016-04-01T02:07:47Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2005-06-30 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.other | 2005-OAK-0000005269 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/24483 | - |
dc.description.abstract | Phospholipase C-gamma 1, containing two SH2 and one SH3 domains which participate in the interaction between signaling molecules, plays a significant role in the growth factor-induced signal transduction. However, the role of the SH domains in the growth factor-induced PLC-gamma 1 regulation is unclear. By peptide-mass fingerprinting analysis, we have identified SHIN as the binding protein for the SH3 domain of PLC-gamma 1. SHIP1 was co-immunoprecipitated with PLC-gamma 1 and potentiated EGF-induced PLC-gamma 1 activation. However, inositol 5'-phosphatase activity of SHIN was not required for the potentiation of EGF-induced PLC-gamma 1 activation. Taken together, these results suggest that SHIP1 may function as an adaptor protein which can potentiate EGF-induced PLC-gamma 1 activation without regards to its inositol 5'-phosphatase activity. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.title | Inositol 5 '-phosphatase, SHIP1 interacts with phospholipase C-gamma 1 and modulates EGF-induced PLC activity | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/emm.2005.22 | - |
dc.author.google | Song, M | - |
dc.author.google | Kim, MJ | - |
dc.author.google | Ha, S | - |
dc.author.google | Park, JB | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 37 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 161 | - |
dc.relation.lastpage | 168 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.37, no.3, pp.161 - 168 | - |
dc.identifier.wosid | 000230510800003 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 168 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 161 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 37 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-22244447751 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 9 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TYROSINE-PHOSPHORYLATED PROTEIN | - |
dc.subject.keywordPlus | C-GAMMA-1 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SRC | - |
dc.subject.keywordPlus | SHC | - |
dc.subject.keywordPlus | 5-PHOSPHATASE | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | PHOSPHATASE | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | DOMAINS | - |
dc.subject.keywordAuthor | epidermal growth factor | - |
dc.subject.keywordAuthor | phospholipase | - |
dc.subject.keywordAuthor | C-gamma 1 | - |
dc.subject.keywordAuthor | SH2 domain-containing inositol 5 &apos | - |
dc.subject.keywordAuthor | -phosphatase | - |
dc.subject.keywordAuthor | SH3 domain | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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