DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHAE, HD | - |
dc.contributor.author | KIM, KT | - |
dc.date.accessioned | 2016-03-31T14:33:43Z | - |
dc.date.available | 2016-03-31T14:33:43Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 1995-01-17 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 1995-OAK-0000009029 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21863 | - |
dc.description.abstract | To test the role of cytosolic calcium in the basal expression of a neuronal gene, promoter activity of the rat tyrosine hydroxylase (TH) gene was monitored upon reduced resting level of intracellular calcium. TH promoter activity was decreased by cell-permeable calcium chelator, BAPTA/AM, in SK-N-BE(2)C human neuroblastoma cells. The cAMP response element (CRE) was mapped to the calcium responsible element by mutational and deletional analysis of the 5' upstream promoter region. Gel shift assay showed 2 CRE-specific DNA-protein complexes. The quantities of specific complexes were markedly decreased in BAPTA/AM-treated cells. These data suggest that resting level of intracellular calcium has a critical role in the basal expression of TH gene through the regulation of the binding of nuclear proteins to the CRE motif in the promoter. (C) 1995 Academic Press, Inc. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC JNL-COMP SUBSCRIPT | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | CELL-SPECIFIC EXPRESSION | - |
dc.subject | NERVE GROWTH-FACTOR | - |
dc.subject | MEMBRANE DEPOLARIZATION | - |
dc.subject | CHLORAMPHENICOL ACETYLTRANSFERASE | - |
dc.subject | REGULATORY ELEMENTS | - |
dc.subject | RESPONSIVE ELEMENT | - |
dc.subject | CYCLIC-AMP | - |
dc.subject | PC12 CELLS | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | PHOSPHORYLATION | - |
dc.title | CYTOSOLIC CALCIUM IS ESSENTIAL IN TBE BASAL EXPRESSION OF TYROSINE-HYDROXYLASE GENE | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1006/bbrc.1995.1093 | - |
dc.author.google | CHAE, HD | - |
dc.author.google | KIM, KT | - |
dc.relation.volume | 206 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 659 | - |
dc.relation.lastpage | 666 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.206, no.2, pp.659 - 666 | - |
dc.identifier.wosid | A1995QC11500032 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 666 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 659 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 206 | - |
dc.contributor.affiliatedAuthor | KIM, KT | - |
dc.identifier.scopusid | 2-s2.0-0028931834 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 11 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CELL-SPECIFIC EXPRESSION | - |
dc.subject.keywordPlus | NERVE GROWTH-FACTOR | - |
dc.subject.keywordPlus | MEMBRANE DEPOLARIZATION | - |
dc.subject.keywordPlus | CHLORAMPHENICOL ACETYLTRANSFERASE | - |
dc.subject.keywordPlus | REGULATORY ELEMENTS | - |
dc.subject.keywordPlus | RESPONSIVE ELEMENT | - |
dc.subject.keywordPlus | CYCLIC-AMP | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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