DC Field | Value | Language |
---|---|---|
dc.contributor.author | HAN, DS | - |
dc.contributor.author | HAHM, B | - |
dc.contributor.author | RHO, HM | - |
dc.contributor.author | JANG, SK | - |
dc.date.accessioned | 2016-03-31T14:31:22Z | - |
dc.date.available | 2016-03-31T14:31:22Z | - |
dc.date.created | 2009-08-19 | - |
dc.date.issued | 1995-04 | - |
dc.identifier.issn | 0022-1317 | - |
dc.identifier.other | 1995-OAK-0000009098 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21815 | - |
dc.description.abstract | NS3 of hepatitis C virus (HCV) is a serine protease that carries out the proteolytic processing of the nonstructural proteins of the HCV polyprotein. Deletion analysis of the N terminus of NS2,3,4 fusion protein revealed that the N-terminal boundary of the active protease resides between amino acids 1050 and 1083. The processing patterns of internal deletion mutants of NS2,3,4 indicated that the C terminus of the enzymically active protease resides between amino acids 1115 and 1218. The N- and C-terminal boundaries of the protease were also confirmed by determining the tr ans-cleavage activity of internally deleted NS3,4. NS3 protease activity was inhibited by Cu2+ but was slightly enhanced by Zn2+. This report provides a possible approach for development of antiviral agents based on protease inhibitors. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SOC GENERAL MICROBIOLOGY | - |
dc.relation.isPartOf | JOURNAL OF GENERAL VIROLOGY | - |
dc.subject | NON-B-HEPATITIS | - |
dc.subject | NON-A | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | STRUCTURAL REGION | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | CORE PROTEIN | - |
dc.subject | ENTRY SITE | - |
dc.subject | EXPRESSION | - |
dc.subject | POLYPROTEIN | - |
dc.subject | RNA | - |
dc.title | IDENTIFICATION OF THE PROTEASE DOMAIN IN NS3 OF HEPATITIS-C VIRUS | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1099/0022-1317-76-4-985 | - |
dc.author.google | HAN, DS | - |
dc.author.google | HAHM, B | - |
dc.author.google | RHO, HM | - |
dc.author.google | JANG, SK | - |
dc.relation.volume | 76 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 985 | - |
dc.relation.lastpage | 993 | - |
dc.contributor.id | 10088382 | - |
dc.relation.journal | JOURNAL OF GENERAL VIROLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF GENERAL VIROLOGY, v.76, no.4, pp.985 - 993 | - |
dc.identifier.wosid | A1995QR22600030 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 993 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 985 | - |
dc.citation.title | JOURNAL OF GENERAL VIROLOGY | - |
dc.citation.volume | 76 | - |
dc.contributor.affiliatedAuthor | JANG, SK | - |
dc.identifier.scopusid | 2-s2.0-0028960558 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 36 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NON-B-HEPATITIS | - |
dc.subject.keywordPlus | NON-A | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | STRUCTURAL REGION | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | CORE PROTEIN | - |
dc.subject.keywordPlus | ENTRY SITE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | POLYPROTEIN | - |
dc.subject.keywordPlus | RNA | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Virology | - |
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