DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, TJ | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T14:24:05Z | - |
dc.date.available | 2016-03-31T14:24:05Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 1996-01 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.other | 1996-OAK-0000009312 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21654 | - |
dc.description.abstract | Forskolin has been used to stimulate adenylyl cyclase. However, we found that forskolin inhibited voltage-sensitive Ca2+ channels (VSCCs) in a cyclic AMP (cAMP)-independent manner in PC12 cells. Ca2+ influx induced by membrane depolarization with 70 mM K+ was inhibited when cells were preincubated with 10 mu M forskolin. Almost maximum inhibitory effect on Ca2+ influx without any significant increase in cellular cAMP level was observed in PC12 cells exposed to forskolin for 1 min. In addition, the forskolin effect on Ca2+ influx was not affected by the presence of 2',5'-dideoxyadenosine, an inhibitor of adenylyl cyclase that reduces dramatically forskolin-induced cAMP production. 1,9-Dideoxyforskolin, an inactive analogue of forskolin, also inhibited similar to 80% of Ca2+ influx induced by 70 mM K+ without any increase in cAMP. The data suggest that forskolin and its analogue inhibit VSCCs in PC12 cells and that the inhibition is independent of cAMP generation. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT-RAVEN PUBL | - |
dc.relation.isPartOf | JOURNAL OF NEUROCHEMISTRY | - |
dc.subject | forskolin | - |
dc.subject | calcium channels | - |
dc.subject | adenylyl cyclase | - |
dc.subject | PC12 cells | - |
dc.subject | RAT PHEOCHROMOCYTOMA CELLS | - |
dc.subject | NERVE GROWTH-FACTOR | - |
dc.subject | GLUCOSE-TRANSPORT | - |
dc.subject | ADENYLATE-CYCLASE | - |
dc.subject | MEMBRANES | - |
dc.subject | BINDING | - |
dc.subject | ACTIVATION | - |
dc.subject | ADIPOCYTES | - |
dc.subject | DITERPENE | - |
dc.subject | RECEPTORS | - |
dc.title | Cyclic AMP-Independent inhibition of voltage-sensitive calcium channels by forskolin in PC12 cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1046/j.1471-4159.1996.66010083.x | - |
dc.author.google | Park, TJ | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 66 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 83 | - |
dc.relation.lastpage | 88 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | JOURNAL OF NEUROCHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROCHEMISTRY, v.66, no.1, pp.83 - 88 | - |
dc.identifier.wosid | A1996TK60300011 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 88 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 83 | - |
dc.citation.title | JOURNAL OF NEUROCHEMISTRY | - |
dc.citation.volume | 66 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0030052632 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 24 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RAT PHEOCHROMOCYTOMA CELLS | - |
dc.subject.keywordPlus | NERVE GROWTH-FACTOR | - |
dc.subject.keywordPlus | GLUCOSE-TRANSPORT | - |
dc.subject.keywordPlus | ADENYLATE-CYCLASE | - |
dc.subject.keywordPlus | MEMBRANES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ADIPOCYTES | - |
dc.subject.keywordPlus | DITERPENE | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordAuthor | forskolin | - |
dc.subject.keywordAuthor | calcium channels | - |
dc.subject.keywordAuthor | adenylyl cyclase | - |
dc.subject.keywordAuthor | PC12 cells | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.