Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains
SCIE
SCOPUS
- Title
- Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains
- Authors
- Chung, KM; Song, OK; Jang, SK
- Date Issued
- 1997-10-31
- Publisher
- KOREAN SOC MOLECULAR BIOLOGY
- Abstract
- Hepatitis C virus (HCV), a major etiologic agent of transfusion associated hepatitis, is a positive, single-stranded RNA virus and is also known to be implicated in liver cirrhosis and hepatocellular carcinoma. Nonstructural protein 5A (NS5A) of HCV contains acidic and proline-rich amino acids in its carboxy-terminal half. These structural features resemble eukaryotic transcription activators. In this report, we show that NS5A functions as a potent transcriptional activator when fused to the yeast (Saccharomyces cerevisiae) GAL4 DNA-binding domain (1-147). The potential transcriptional activator maps to the C-terminal half of NS5A in the yeast cell. Therefore, our data provides the first evidence that NS5A may modulate host cell function at the transcriptional level.
- Keywords
- NON-B-HEPATITIS; SERINE PROTEINASE; DNA-BINDING; NON-A; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION; NS5A REGION; YEAST; NS3; POLYPROTEIN
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/21186
- ISSN
- 1016-8478
- Article Type
- Article
- Citation
- MOLECULES AND CELLS, vol. 7, no. 5, page. 661 - 667, 1997-10-31
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- There are no files associated with this item.
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