DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, TJ | - |
dc.contributor.author | Lee, IS | - |
dc.contributor.author | Ha, H | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T13:44:02Z | - |
dc.date.available | 2016-03-31T13:44:02Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 1999-02-28 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 1999-OAK-0000000638 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20482 | - |
dc.description.abstract | The effects of temperature on ion fluxes and catecholamine secretion that are mediated by nicotinic acetylcholine receptors (nAChRs), voltage-sensitive calcium channels (VSCCs), and voltage-sensitive sodium channels (VSSCs) were investigated using bovine adrenal chromaffin cells, When the chromaffin cells were stimulated with DMPP, a nicotinic cholinergic agonist, or 50 mM K+, the intracellular calcium ([Ca2+](i)) elevation reached a peak and decreased more slowly at lower temperatures. The DMPP-induced responses were more sensitive to temperature changes compared to high K+-induced ones. In the measurement of intracellular sodium concentrations ([Na+](i)), it was found that nicotinic stimulation required a longer time to attain the maximal level of [Na+](i) at lower temperatures. In addition, the VSSCs-mediated [Na+](i) increase evoked by veratridine was also reduced as the temperature decreased. The measurement of [H-3]norepinephrine (NE) secretion showed that the secretion within the first 3 min evoked by DMPP or high K+ was greatest at 37 degrees C. However, at 25 degrees C, the secretion evoked by DMPP, but not that by the 50 mM K+, was greater after 10 min of stimulation, This data suggest that temperature differentially affects the activity of nAChRs, VSCCs, and VSSCs, resulting in differential [Na+](i) and [Ca2+](i) elevation, and in the [H-3]NE secretion by adrenal chromaffin cells. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | calcium channel | - |
dc.subject | catecholamine secretion | - |
dc.subject | nicotinic receptor | - |
dc.subject | sodium channels | - |
dc.subject | temperature | - |
dc.subject | MEDULLA CELLS | - |
dc.subject | CA2+ | - |
dc.subject | PC12 | - |
dc.title | Temperature sensitivity of catecholamine secretion and ion fluxes in bovine adrenal chromaffin cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Park, TJ | - |
dc.author.google | Lee, IS | - |
dc.author.google | Ha, H | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 9 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 67 | - |
dc.relation.lastpage | 71 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.9, no.1, pp.67 - 71 | - |
dc.identifier.wosid | 000078881400012 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 71 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 67 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0033611638 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 8 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MEDULLA CELLS | - |
dc.subject.keywordPlus | CA2+ | - |
dc.subject.keywordPlus | PC12 | - |
dc.subject.keywordAuthor | calcium channel | - |
dc.subject.keywordAuthor | catecholamine secretion | - |
dc.subject.keywordAuthor | nicotinic receptor | - |
dc.subject.keywordAuthor | sodium channels | - |
dc.subject.keywordAuthor | temperature | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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