DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, UG | - |
dc.contributor.author | Kim, MJ | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Park, JB | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Lee, YH | - |
dc.date.accessioned | 2016-03-31T13:35:22Z | - |
dc.date.available | 2016-03-31T13:35:22Z | - |
dc.date.created | 2009-08-12 | - |
dc.date.issued | 1999-12-31 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 2000-OAK-0000001096 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20163 | - |
dc.description.abstract | Trifluoperazine (TFP), a phenothiazine antipsychotic agent with calmodulin antagonist property, induces DNA fragmentation in a dose- and time-dependent manner in PC12 cells, Various agents affecting calcium mediated intracellular signal transduction such as calcium chelators, calcium ionopores, inhibitors of phospholipase C, and activators/inhibitors of protein kinase C did not block TFP-induced DNA fragmentation, Some of these agents themselves induced DNA fragmentation in the conditions under which they were examined, However, cholera toxin (selective Gs activator), forskolin (adenylate cyclase activator) or dibutyryl cyclic AMP (cyclic AMP analogue) inhibited TFP-induced DNA fragmentation in a dose-dependent manner. These results suggest that it is not the calcium but the Gs and adenylate cyclase pathways that play an important role in TFP-induced DNA fragmentation in PC12 cells. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | calcium | - |
dc.subject | calmodulin | - |
dc.subject | cyclic AMP | - |
dc.subject | DNA fragmentation | - |
dc.subject | PC12 cell | - |
dc.subject | trifluoperazine | - |
dc.subject | PC12 CELLS | - |
dc.subject | CALMODULIN ANTAGONISTS | - |
dc.subject | ANTIPSYCHOTIC-DRUGS | - |
dc.subject | PHOSPHOLIPASE-C | - |
dc.subject | GLIOMA-CELLS | - |
dc.subject | IN-VITRO | - |
dc.subject | APOPTOSIS | - |
dc.subject | DEATH | - |
dc.subject | CHLORPROMAZINE | - |
dc.subject | NECROSIS | - |
dc.title | Inhibition of trifluoperazine-induced DNA fragmentation by cyclic AMP mediated signaling | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Kang, UG | - |
dc.author.google | Kim, MJ | - |
dc.author.google | Suh, PG | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Park, JB | - |
dc.author.google | Kim, JH | - |
dc.author.google | Kim, YS | - |
dc.author.google | Lee, YH | - |
dc.relation.volume | 9 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 596 | - |
dc.relation.lastpage | 602 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.9, no.6, pp.596 - 602 | - |
dc.identifier.wosid | 000084460500004 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 602 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 596 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-0033621288 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 8 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | CALMODULIN ANTAGONISTS | - |
dc.subject.keywordPlus | ANTIPSYCHOTIC-DRUGS | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C | - |
dc.subject.keywordPlus | GLIOMA-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | CHLORPROMAZINE | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordAuthor | calcium | - |
dc.subject.keywordAuthor | calmodulin | - |
dc.subject.keywordAuthor | cyclic AMP | - |
dc.subject.keywordAuthor | DNA fragmentation | - |
dc.subject.keywordAuthor | PC12 cell | - |
dc.subject.keywordAuthor | trifluoperazine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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