DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, YJ | - |
dc.contributor.author | Hur, EM | - |
dc.contributor.author | Park, TJ | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T13:31:16Z | - |
dc.date.available | 2016-03-31T13:31:16Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 2000-06 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.other | 2000-OAK-0000001313 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20011 | - |
dc.description.abstract | We investigated the effects of 17 beta-estradiol, an estrogen, on [H-3]norepinephrine ([H-3]NE) secretion in PC12 cells. Pretreatment with 17 beta-estradiol reduced 70 mM K+-induced [H-3]NE secretion in a concentrationdependent manner with a half-maximal inhibitory concentration (IC50) of 2 +/- 1 mu M. The 70 mM K+-induced cytosolic free Ca2+ concentration ([Ca2+](i)) rise was also reduced when the cells were treated with 17 beta-estradiol (IC50 = 15 +/- 2 mu M). Studies with voltage-sensitive calcium channel (VSCC) antagonists such as nifedipine and omega-conotoxin GVIA revealed that both L- and N-type VSCCs were affected by 17 beta-estradiol treatment. The 17 beta-estradiol effect was not changed by pretreatment of the cells with actinomycin D and cycloheximide for 5 h. In addition, treatment with pertussis or cholera toxin did not affect the inhibitory effect of 17 beta-estradiol. 17 beta-Estradiol also inhibited the ATP-induced [H-3]NE secretion and [Ca2+](i) rise. In PC12 cells, the ATP-induced [Ca2+](i) rise is known to occur through P2X(2) receptors, the P2Y(2)-mediated phospholipase C (PLC) pathway, and VSCCs. 17 beta-Estradiol pretreatment during complete inhibition of the PLC pathway and VSCCs inhibited the ATP-induced [Ca2+](i) rise. Our results suggest that 17 beta-estradiol inhibits catecholamine secretion by inhibiting L- and N-type Ca2+ channels and P2X(2) receptors in a nongenomic manner. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | JOURNAL OF NEUROCHEMISTRY | - |
dc.subject | 17 beta-estradiol | - |
dc.subject | catecholamine secretion | - |
dc.subject | nongenomic inhibition | - |
dc.subject | voltage-sensitive calcium channel | - |
dc.subject | P2X(2) receptor | - |
dc.subject | PC12 cell | - |
dc.subject | VASCULAR SMOOTH-MUSCLE | - |
dc.subject | SENSITIVE CALCIUM CHANNELS | - |
dc.subject | STEROID-HORMONES | - |
dc.subject | CA2+ CURRENTS | - |
dc.subject | RECEPTORS | - |
dc.subject | ESTRADIOL | - |
dc.subject | RESPONSES | - |
dc.subject | BINDING | - |
dc.title | Nongenomic inhibition of catecholamine secretion by 17 beta-estradiol in PC12 cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1046/j.1471-4159.2000.0742490.x | - |
dc.author.google | Kim, YJ | - |
dc.author.google | Hur, EM | - |
dc.author.google | Park, TJ | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 74 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 2490 | - |
dc.relation.lastpage | 2496 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | JOURNAL OF NEUROCHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROCHEMISTRY, v.74, no.6, pp.2490 - 2496 | - |
dc.identifier.wosid | 000086968800029 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 2496 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2490 | - |
dc.citation.title | JOURNAL OF NEUROCHEMISTRY | - |
dc.citation.volume | 74 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0034025016 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 47 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | VASCULAR SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | SENSITIVE CALCIUM CHANNELS | - |
dc.subject.keywordPlus | STEROID-HORMONES | - |
dc.subject.keywordPlus | CA2+ CURRENTS | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | ESTRADIOL | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordAuthor | 17 beta-estradiol | - |
dc.subject.keywordAuthor | catecholamine secretion | - |
dc.subject.keywordAuthor | nongenomic inhibition | - |
dc.subject.keywordAuthor | voltage-sensitive calcium channel | - |
dc.subject.keywordAuthor | P2X(2) receptor | - |
dc.subject.keywordAuthor | PC12 cell | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
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