DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, YH | - |
dc.contributor.author | Bae, SS | - |
dc.contributor.author | Seo, JK | - |
dc.contributor.author | Choi, I | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-03-31T13:27:48Z | - |
dc.date.available | 2016-03-31T13:27:48Z | - |
dc.date.created | 2009-08-12 | - |
dc.date.issued | 2000-08-31 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 2000-OAK-0000001512 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19881 | - |
dc.description.abstract | Phospholipase C (PLC)-gamma 1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-gamma 1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-gamma 1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine, These results suggest-that PLC-gamma 1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | interleukin-6 | - |
dc.subject | PC12 cells | - |
dc.subject | phospholipase C-gamma 1 | - |
dc.subject | signal transduction | - |
dc.subject | tyrosine phosphorylation | - |
dc.subject | NERVE GROWTH-FACTOR | - |
dc.subject | LEUKEMIA INHIBITORY FACTOR | - |
dc.subject | SIGNAL TRANSDUCER GP130 | - |
dc.subject | CYTOKINE RECEPTORS | - |
dc.subject | NEURITE OUTGROWTH | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | C-GAMMA | - |
dc.subject | ACTIVATION | - |
dc.subject | KINASES | - |
dc.subject | DIFFERENTIATION | - |
dc.title | Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Lee, YH | - |
dc.author.google | Bae, SS | - |
dc.author.google | Seo, JK | - |
dc.author.google | Choi, I | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 10 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 469 | - |
dc.relation.lastpage | 474 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.10, no.4, pp.469 - 474 | - |
dc.identifier.wosid | 000088939500017 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 474 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 469 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 10 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NERVE GROWTH-FACTOR | - |
dc.subject.keywordPlus | LEUKEMIA INHIBITORY FACTOR | - |
dc.subject.keywordPlus | SIGNAL TRANSDUCER GP130 | - |
dc.subject.keywordPlus | CYTOKINE RECEPTORS | - |
dc.subject.keywordPlus | NEURITE OUTGROWTH | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | C-GAMMA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | KINASES | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordAuthor | interleukin-6 | - |
dc.subject.keywordAuthor | PC12 cells | - |
dc.subject.keywordAuthor | phospholipase C-gamma 1 | - |
dc.subject.keywordAuthor | signal transduction | - |
dc.subject.keywordAuthor | tyrosine phosphorylation | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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