DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Hahm, B | - |
dc.contributor.author | Jang, SK | - |
dc.date.accessioned | 2016-03-31T13:24:39Z | - |
dc.date.available | 2016-03-31T13:24:39Z | - |
dc.date.created | 2009-08-19 | - |
dc.date.issued | 2000-11-24 | - |
dc.identifier.issn | 0022-2836 | - |
dc.identifier.other | 2000-OAK-0000001676 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19763 | - |
dc.description.abstract | Translation initiation of human Bip mRNA is directed by an internal ribosomal entry site (IRES) located in the 5' non-translated region. No trans-acting factor possibly involved in this process has as of yet been identified. For the encephalomyocarditis virus and other picornaviruses, polypyrimidine tract-binding protein (PTB) has been found to enhance the translation through IRES elements, probably by interaction with the IRES structure. Here, we report that PTB specifically binds to the central region (nt 50-117) of the Bip 5' non-translated region. Addition of purified PTB to rabbit reticulocyte lysate and overexpression of PTB in Cos-7 cells selectively inhibited Bip IRES-dependent translation On the other hand, depletion of endogenous PTB or addition of an RNA interacting with PTB enhanced the translational initiation directed by Bip IRES. These suggest that PTB can either enhance or inhibit IRES-dependent translation depending on mRNAs. (C) 2000 Academic Press. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS LTD | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.subject | translation | - |
dc.subject | Bip | - |
dc.subject | IRES | - |
dc.subject | PTB | - |
dc.subject | ENCEPHALOMYOCARDITIS VIRUS-RNA | - |
dc.subject | RIBOSOME ENTRY SITE | - |
dc.subject | CAP-INDEPENDENT TRANSLATION | - |
dc.subject | 5&apos | - |
dc.subject | NONTRANSLATED REGION | - |
dc.subject | GLUCOSE-REGULATED PROTEINS | - |
dc.subject | HUMAN RHINOVIRUS RNA | - |
dc.subject | MOUTH-DISEASE VIRUS | - |
dc.subject | ROUS-SARCOMA VIRUS | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | INTERNAL INITIATION | - |
dc.title | Polypyrimidine tract-binding protein inhibits translation of Bip mRNA | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1006/jmbi.2000.4179 | - |
dc.author.google | Kim, YK | - |
dc.author.google | Hahm, B | - |
dc.author.google | Jang, SK | - |
dc.relation.volume | 304 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 119 | - |
dc.relation.lastpage | 133 | - |
dc.contributor.id | 10088382 | - |
dc.relation.journal | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR BIOLOGY, v.304, no.2, pp.119 - 133 | - |
dc.identifier.wosid | 000165670100001 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 133 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 119 | - |
dc.citation.title | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.citation.volume | 304 | - |
dc.contributor.affiliatedAuthor | Jang, SK | - |
dc.identifier.scopusid | 2-s2.0-0034711379 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 59 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ENCEPHALOMYOCARDITIS VIRUS-RNA | - |
dc.subject.keywordPlus | RIBOSOME ENTRY SITE | - |
dc.subject.keywordPlus | CAP-INDEPENDENT TRANSLATION | - |
dc.subject.keywordPlus | 5&apos | - |
dc.subject.keywordPlus | NONTRANSLATED REGION | - |
dc.subject.keywordPlus | GLUCOSE-REGULATED PROTEINS | - |
dc.subject.keywordPlus | HUMAN RHINOVIRUS RNA | - |
dc.subject.keywordPlus | MOUTH-DISEASE VIRUS | - |
dc.subject.keywordPlus | ROUS-SARCOMA VIRUS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | INTERNAL INITIATION | - |
dc.subject.keywordAuthor | translation | - |
dc.subject.keywordAuthor | Bip | - |
dc.subject.keywordAuthor | IRES | - |
dc.subject.keywordAuthor | PTB | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.