DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, CH | - |
dc.contributor.author | Choi, YH | - |
dc.contributor.author | Yang, SH | - |
dc.contributor.author | Lee, CW | - |
dc.contributor.author | Ha, SJ | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-03-31T13:23:15Z | - |
dc.date.available | 2016-03-31T13:23:15Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2001-01-05 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.other | 2001-OAK-0000001748 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19711 | - |
dc.description.abstract | A characteristic feature of hepatitis C virus (HCV) infection is a high frequency of persistence and the progression to chronic liver diseases. Recent data suggest that prevalent T helper (Th) 2 immunity as well as weak HCV-specific T-cell response is associated with viral persistence. Here, we showed that the production of interleukin 12 (IL-12) and nitric oxide (NO) that is critical for the induction of Th1 and innate immunity, but not that of tumor necrosis factor alpha (TNF-alpha), was significantly suppressed in both HCV core-expressing macrophage cell lines and mouse peritoneal macrophages treated with recombinant core protein. in addition, IL-12 p40 promoter activity was repressed by the presence of HCV core in macrophages stimulated with lipopolysaccharride (LPS) following IFN-gamma treatment, indicating that IL-12 production may be downregulated at the transcriptional level. We also found that proliferation of T cells and IFN-gamma , production in mixed lymphocyte reactions (MLR) with core-expressing cells were inhibited. Taken together, our results suggest that HCV core protein could play roles in suppressing the induction of Th1 immunity through inhibition of IL-12 and NO production. (C) 2001 Academic Press. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC | - |
dc.relation.isPartOf | VIROLOGY | - |
dc.subject | BLOOD MONONUCLEAR-CELLS | - |
dc.subject | T-HELPER CELLS | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | HEMATOPOIETIC-CELLS | - |
dc.subject | IL-12 PRODUCTION | - |
dc.subject | IMMUNE-RESPONSE | - |
dc.subject | IN-VIVO | - |
dc.subject | INFECTION | - |
dc.subject | KINASE | - |
dc.subject | INTERFERON | - |
dc.title | Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1006/viro.2000.0694 | - |
dc.author.google | Lee, CH | - |
dc.author.google | Choi, YH | - |
dc.author.google | Yang, SH | - |
dc.author.google | Lee, CW | - |
dc.author.google | Ha, SJ | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 279 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 271 | - |
dc.relation.lastpage | 279 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | VIROLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | VIROLOGY, v.279, no.1, pp.271 - 279 | - |
dc.identifier.wosid | 000166516300026 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 279 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 271 | - |
dc.citation.title | VIROLOGY | - |
dc.citation.volume | 279 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0035916008 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 59 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BLOOD MONONUCLEAR-CELLS | - |
dc.subject.keywordPlus | T-HELPER CELLS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | HEMATOPOIETIC-CELLS | - |
dc.subject.keywordPlus | IL-12 PRODUCTION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | INTERFERON | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
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