DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, ZH | - |
dc.contributor.author | Lee, SE | - |
dc.contributor.author | Kwack, KB | - |
dc.contributor.author | Yeo, W | - |
dc.contributor.author | Lee, TH | - |
dc.contributor.author | Bae, SS | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Kim, HH | - |
dc.date.accessioned | 2016-03-31T13:21:05Z | - |
dc.date.available | 2016-03-31T13:21:05Z | - |
dc.date.created | 2009-03-19 | - |
dc.date.issued | 2001-03 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.other | 2001-OAK-0000001868 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19629 | - |
dc.description.abstract | The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) proteins play a central role in the early steps of signal transduction by TNFR superfamily proteins, which induce various cellular responses, including apoptosis, Influences of TRAF proteins on the regulation of cell death and physical interactions between TRAFs and caspases have been reported. In this study, we demonstrate that TRAF3 is proteolyzed during cell death in a caspase-dependent manner, TRAF3 was found to be cleaved by incubation with caspase3 in vitro and by Fas- or CD3-triggering in Jurkat-T cells. The Fas- or CDS-induced cleavage of TRAF3 was Mocked by caspase inhibitors and by introduction of alanine substitutions for D-347 and D-367 residues. Furthermore, the amino-terminal fragment of TRAF3 showed a different intracellular localization from the full-length TRAF3 with preferential distribution to particulate fractions and the nucleus. These findings suggest that TRAF3 may be regulated by caspases during apoptosis of T cells. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.relation.isPartOf | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.subject | tumor necrosis factor receptor-associated factor | - |
dc.subject | apoptosis | - |
dc.subject | tumor necrosis factor receptor superfamily | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | RECEPTOR-ASSOCIATED FACTOR-2 | - |
dc.subject | LYMPHOTOXIN-BETA RECEPTOR | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | ADAPTER PROTEINS | - |
dc.subject | TERMINAL KINASE | - |
dc.subject | JNK ACTIVATION | - |
dc.subject | FAMILY | - |
dc.subject | DEATH | - |
dc.subject | TNF | - |
dc.title | Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Lee, ZH | - |
dc.author.google | Lee, SE | - |
dc.author.google | Kwack, KB | - |
dc.author.google | Yeo, W | - |
dc.author.google | Lee, TH | - |
dc.author.google | Bae, SS | - |
dc.author.google | Suh, PG | - |
dc.author.google | Kim, HH | - |
dc.relation.volume | 69 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 490 | - |
dc.relation.lastpage | 496 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.69, no.3, pp.490 - 496 | - |
dc.identifier.wosid | 000167514600023 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 496 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 490 | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 69 | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 14 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ADAPTER PROTEINS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | TNF | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | JNK | - |
dc.subject.keywordAuthor | tumor necrosis factor receptor-associated factor | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | tumor necrosis factor receptor superfamily | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
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