DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, F | - |
dc.contributor.author | Moon, KA | - |
dc.contributor.author | Kim, SS | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Choi, YK | - |
dc.contributor.author | Bae, YS | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Choi, EJ | - |
dc.contributor.author | Ha, J | - |
dc.contributor.author | Kim, SS | - |
dc.date.accessioned | 2016-03-31T13:19:58Z | - |
dc.date.available | 2016-03-31T13:19:58Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2001-04-06 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 2001-OAK-0000001927 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19589 | - |
dc.description.abstract | Insulin-like growth factor-I (IGF-I) regulates muscle differentiation through phosphatidylinositol 3-kinase (PI 3-kinase), Also it was recently reported that PI 3-kinase is involved in the activation of phospholipase C-gamma1 (PLC-gamma1), We investigated whether PLC-gamma1 therefore plays a role in IGF-I-induced muscle differentiation using H9c2 rat cardiac myoblasts as a model. IGF-I was able to activate PLC-gamma1 via both PI3-kinase-dependent and tyrosine phosphorylation-dependent mechanisms in this model. However, PI 3-kinase appeared to play a more important role than tyrosine phosphorylation in IGF-I activation of PLC-gamma1, In addition, PLC-gamma1. activation was independent of Akt/ protein kinase B (Akt/PKB), Importantly, PLC-gamma1 was involved in IGF-I-induced muscle differentiation in parallel with Akt/PKB, Taken together, these results suggest that IGF-I regulation of muscle differentiation is dependent on the activation of PLC-gamma1 and Akt/PKB, both of which are downstream mediators of PI 3-kinase. (C) 2001 Academic Press. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject | C-GAMMA | - |
dc.subject | MYOGENIC DIFFERENTIATION | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | SKELETAL MYOGENESIS | - |
dc.subject | P38 | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | INHIBITORS | - |
dc.subject | ISOZYMES | - |
dc.title | Role of phospholipase C-gamma 1 in insulin-like growth factor I-induced muscle differentiation of H9c2 cardiac myoblasts | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1006/bbrc.2001.4644 | - |
dc.author.google | Hong, F | - |
dc.author.google | Moon, KA | - |
dc.author.google | Kim, SS | - |
dc.author.google | Kim, YS | - |
dc.author.google | Choi, YK | - |
dc.author.google | Bae, YS | - |
dc.author.google | Suh, PG | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Choi, EJ | - |
dc.author.google | Ha, J | - |
dc.relation.volume | 282 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 816 | - |
dc.relation.lastpage | 822 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.282, no.3, pp.816 - 822 | - |
dc.identifier.wosid | 000168092000027 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 822 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 816 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 282 | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-0034814451 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 18 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject.keywordPlus | C-GAMMA | - |
dc.subject.keywordPlus | MYOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | SKELETAL MYOGENESIS | - |
dc.subject.keywordPlus | P38 | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | ISOZYMES | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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