DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, KH | - |
dc.contributor.author | Kim, KC | - |
dc.contributor.author | Jung, YJ | - |
dc.contributor.author | Ham, YH | - |
dc.contributor.author | Jang, JJ | - |
dc.contributor.author | Kwon, H | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Han, SK | - |
dc.contributor.author | Kim, CM | - |
dc.date.accessioned | 2016-03-31T13:15:19Z | - |
dc.date.available | 2016-03-31T13:15:19Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2001-08-31 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 2001-OAK-0000002170 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19415 | - |
dc.description.abstract | We investigated the role of wild-type (wt)-p53 as an inducer of apoptotic cell death in human hepatoma cell lines. Following the retrovirus-mediated transduction of the wt-p53 gene, Hep3B cells lacking the endogenous p53 expression began to die through apoptosis in 4 h. They showed a maximal apoptotic death at 12 h, whereas HepG2 cells expressing endogenous p53 did not. However, the transduction of the wt-p53 gene elicited growth suppression of both Hep3B and HepG2 cells. P21(WAF1/CIP1), a p53-inducible cell cycle inhibitor, was induced, not only in Hep3B cells undergoing apoptosis, but also in HepG2 cells. The kinetics of the p21(WAF1/CIP1) induction, DNA fragmentation, and growth suppression of the Hep3B cells showed that DNA fragmentation and growth suppression progressed rapidly following p21(WAF1/CIP1) accumulation. N-acetylcysteine or glutathione, potent antioxidants, strongly inhibited the DNA fragmentation, but did not reduce the elevated level of p21(WAF1/CIP1). These findings suggested that p21(WAF1/CIP1) was not a critical mediator for the execution of p53-mediated apoptosis, although it contributed to the growth inhibition of cells undergoing apoptosis. Furthermore, p53-mediated apoptosis could be repressed by antioxidants. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | p21(WAF1-CIP1) | - |
dc.subject | p53 | - |
dc.subject | antioxidant | - |
dc.subject | apoptosis | - |
dc.subject | hepatocellular carcinoma | - |
dc.subject | HUMAN HEPATOCELLULAR CARCINOMAS | - |
dc.subject | LUNG-CANCER CELLS | - |
dc.subject | GROWTH SUPPRESSION | - |
dc.subject | ADENOVIRUS | - |
dc.subject | EXPRESSION | - |
dc.subject | PROTEIN | - |
dc.subject | WAF1/CIP1 | - |
dc.subject | RADICALS | - |
dc.subject | THERAPY | - |
dc.subject | ARREST | - |
dc.title | Induction of apoptosis in p53-deficient human hepatoma cell line by wild-type p53 gene transduction: Inhibition by antioxidant | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Lee, KH | - |
dc.author.google | Kim, KC | - |
dc.author.google | Jung, YJ | - |
dc.author.google | Ham, YH | - |
dc.author.google | Jang, JJ | - |
dc.author.google | Kwon, H | - |
dc.author.google | Sung, YC | - |
dc.author.google | Kim, SH | - |
dc.author.google | Han, SK | - |
dc.author.google | Kim, CM | - |
dc.relation.volume | 12 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 17 | - |
dc.relation.lastpage | 24 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.12, no.1, pp.17 - 24 | - |
dc.identifier.wosid | 000170786800003 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 16 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HUMAN HEPATOCELLULAR CARCINOMAS | - |
dc.subject.keywordPlus | LUNG-CANCER CELLS | - |
dc.subject.keywordPlus | GROWTH SUPPRESSION | - |
dc.subject.keywordPlus | ADENOVIRUS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | WAF1/CIP1 | - |
dc.subject.keywordPlus | RADICALS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ARREST | - |
dc.subject.keywordAuthor | p21(WAF1-CIP1) | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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