DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Y | - |
dc.contributor.author | Lee, SW | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-03-31T13:11:06Z | - |
dc.date.available | 2016-03-31T13:11:06Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2002-01-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2002-OAK-0000002398 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19258 | - |
dc.description.abstract | CpG DNA has been recognized as a powerful stimulant of dendritic cells (DCs). In this study, we demonstrate that CpG DNA inhibits spontaneous apoptosis of DCs. CpG DNA up-regulated cellular inhibitor of apoptosis proteins (cIAPs) as well as Bcl-2 and Bcl-x(L), but down-regulated active caspase-3. Although CpG DNA activated p38 mitogen-activated protein kinase, extracellular signal-related kinase, and phosphatidylinositide-3'-OH kinase (PI3K), only the blocking of PI3K inhibited the CpG DNA-induced DC survival. Moreover, while the expression of Bcl-2 and Bel-x(L) depends on both PI3K and p38 mitogen-activated protein kinase, the up-regulation of cIAPs and the down-regulation of active caspase-3 by CpG DNA require PI3K activation, suggesting PI3K-dependent upregulation of cIAPs in the antiapoptotic activity of CpG DNA in DCs. This study indicates that CpG DNA provides a survival signal to DCs, which might be one of mechanisms by which bacterial DNA stimulates and maintains the innate immune responses. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | ANTIGEN-PRESENTING CELLS | - |
dc.subject | BACTERIAL-DNA | - |
dc.subject | IMMUNOSTIMULATORY DNA | - |
dc.subject | ACTIVATION | - |
dc.subject | SURVIVAL | - |
dc.subject | MATURATION | - |
dc.subject | OLIGODEOXYNUCLEOTIDES | - |
dc.subject | INDUCTION | - |
dc.subject | FAMILY | - |
dc.subject | PLAY | - |
dc.title | Cutting edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3 '-OH kinase pathway | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.168.1.5 | - |
dc.author.google | Park, Y | - |
dc.author.google | Lee, SW | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 168 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 5 | - |
dc.relation.lastpage | 8 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.168, no.1, pp.5 - 8 | - |
dc.identifier.wosid | 000172934000002 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 5 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 168 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0036134876 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 82 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ANTIGEN-PRESENTING CELLS | - |
dc.subject.keywordPlus | BACTERIAL-DNA | - |
dc.subject.keywordPlus | IMMUNOSTIMULATORY DNA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | OLIGODEOXYNUCLEOTIDES | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | PLAY | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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