DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, B | - |
dc.contributor.author | Oh, H | - |
dc.contributor.author | Lee, S | - |
dc.contributor.author | Song, YS | - |
dc.contributor.author | Shin, J | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Hwang, SY | - |
dc.contributor.author | Ahn, K | - |
dc.date.accessioned | 2016-03-31T13:08:12Z | - |
dc.date.available | 2016-03-31T13:08:12Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2002-04-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2002-OAK-0000002543 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19150 | - |
dc.description.abstract | Human CMV encodes four unique short region proteins (US), US2, US3, US6, and US 11, each independently sufficient for causing the down-regulation of MHC class I molecules on the cell surface. This down-regulation allows infected cells to evade recognition by cytotoxic T cells but leaves them susceptible to NK cells, which lyse cells that lack class I molecules. Another human CMV-encoded protein, unique long region protein 18 (UL18), is an MHC class I homolog that might provide a mechanism for inhibiting the NK cell response. The sequence similarities between MHC class I molecules and UL18 along with the ability of UL18 to form trimeric complexes with beta(2)-microglobulin and peptides led to the hypothesis that if the US and UL18 gene products coexist temporally during infection, the US proteins might down-regulate UL18 molecules, similar to their action on MHC class I molecules. We show here that temporal expression of US and UL18 genes partially overlaps during infection. However, unlike MHC class I molecules, the MHC class I homolog, UL18, is fully resistant to the down-regulation associated with the US2, US3, US6, and US11 gene products. The specific effect of US proteins on MHC class I molecules, but not on UL18, represents another example of how viral proteins have evolved to evade immune surveillance, avoiding fratricide by specifically targeting host proteins. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | MAJOR HISTOCOMPATIBILITY COMPLEX | - |
dc.subject | ENDOPLASMIC-RETICULUM | - |
dc.subject | ANTIGEN PRESENTATION | - |
dc.subject | HEAVY-CHAINS | - |
dc.subject | PEPTIDE TRANSLOCATION | - |
dc.subject | KILLER-CELL | - |
dc.subject | VIRUS | - |
dc.subject | MOLECULES | - |
dc.subject | TAP | - |
dc.subject | TRANSPORT | - |
dc.title | The MHC class I homolog of human cytomegalovirus is resistant to down-regulation mediated by the unique short region protein (US)2, US3, US6, and US11 gene products | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.168.7.3464 | - |
dc.author.google | Park, B | - |
dc.author.google | Oh, H | - |
dc.author.google | Lee, S | - |
dc.author.google | Song, YS | - |
dc.author.google | Shin, J | - |
dc.author.google | Sung, YC | - |
dc.author.google | Hwang, SY | - |
dc.author.google | Ahn, K | - |
dc.relation.volume | 168 | - |
dc.relation.issue | 7 | - |
dc.relation.startpage | 3464 | - |
dc.relation.lastpage | 3469 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.168, no.7, pp.3464 - 3469 | - |
dc.identifier.wosid | 000174566400046 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 3469 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 3464 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 168 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0036533565 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 46 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MAJOR HISTOCOMPATIBILITY COMPLEX | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | HEAVY-CHAINS | - |
dc.subject.keywordPlus | PEPTIDE TRANSLOCATION | - |
dc.subject.keywordPlus | KILLER-CELL | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | TAP | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.