DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kong, JS | - |
dc.contributor.author | Yoo, SA | - |
dc.contributor.author | Kang, JH | - |
dc.contributor.author | Ko, W | - |
dc.contributor.author | Jeon, S | - |
dc.contributor.author | Chae, CB | - |
dc.contributor.author | Cho, CS | - |
dc.contributor.author | Kim, WU | - |
dc.date.accessioned | 2016-03-31T09:20:39Z | - |
dc.date.available | 2016-03-31T09:20:39Z | - |
dc.date.created | 2011-12-15 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 0969-6970 | - |
dc.identifier.other | 2011-OAK-0000024397 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17040 | - |
dc.description.abstract | Extensive angiogenesis in the synoviums is a characteristic pathology of rheumatoid arthritis (RA). We have demonstrated that anti-flt-1 hexapeptide, GNQWFI, specifically inhibits the interaction of VEGF or PlGF with its receptor flt-1 (Yoo et al. [13]). In this study, we investigate the feasibility of the synthetic D-form of anti-flt-1 hexapeptide conjugated with 8-amino-3,6-dioxaoctanoic acid (mini-PEG((TM))) for treatment of RA. We first modified the structure of anti-flt-1 peptide from the L-form (GNQWFI) to all D-form (gnqwfi; allD) and then conjugated allD with mini-PEG((TM)) to enhance its stability. The result showed that the allD anti-flt-1 peptide showed an increased stability in the sera without major loss of inhibitory activity. The allD and its mini-PEGylated derivative similarly suppressed wounding migration, chemotaxis, and tube formation of endothelial cells in vitro. However, in the Matrigels assay, the in vivo anti-angiogenic activity of mini-PEGylated allD was stronger than that of native allD or L-form. Moreover, oral and subcutaneous administration of mini-PEGylated allD, but not oral feeding of original L-form, successfully suppressed severity of collagen-induced arthritis. After a single subcutaneous injection, the Cy5-labeled mini-PEGylated allD was found to be distributed systemically and accumulated in arthritic joints of mice, particularly in joints with a severe clinical score. In conclusion, our data suggests that mini-PEGylated allD is more beneficial in the treatment of RA than unmodified anti-flt-1 peptides, since it has increased stability and the possibility of oral delivery, and could be applied to treat angiogenesis-dependent human diseases, including RA. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | ANGIOGENESIS | - |
dc.subject | VEGF | - |
dc.subject | Anti-flt-1 peptide | - |
dc.subject | D-form | - |
dc.subject | Mini-PEG | - |
dc.subject | Angiogenesis | - |
dc.subject | Chronic arthritis | - |
dc.subject | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | INTESTINAL PERMEABILITY | - |
dc.subject | POLYETHYLENE-GLYCOL | - |
dc.subject | ORAL DELIVERY | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | VEGF | - |
dc.subject | BEVACIZUMAB | - |
dc.title | Suppression of neovascularization and experimental arthritis by D-form of anti-flt-1 peptide conjugated with mini-PEG((TM)) | - |
dc.type | Article | - |
dc.contributor.college | 화학공학과 | - |
dc.identifier.doi | 10.1007/S10456-011-9226-0 | - |
dc.author.google | Kong, JS | - |
dc.author.google | Yoo, SA | - |
dc.author.google | Kang, JH | - |
dc.author.google | Ko, W | - |
dc.author.google | Jeon, S | - |
dc.author.google | Chae, CB | - |
dc.author.google | Cho, CS | - |
dc.author.google | Kim, WU | - |
dc.relation.volume | 14 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 431 | - |
dc.relation.lastpage | 442 | - |
dc.contributor.id | 10132035 | - |
dc.relation.journal | ANGIOGENESIS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ANGIOGENESIS, v.14, no.4, pp.431 - 442 | - |
dc.identifier.wosid | 000297118800003 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 442 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 431 | - |
dc.citation.title | ANGIOGENESIS | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Jeon, S | - |
dc.identifier.scopusid | 2-s2.0-84855187018 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 8 | - |
dc.description.scptc | 8 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | INTESTINAL PERMEABILITY | - |
dc.subject.keywordPlus | POLYETHYLENE-GLYCOL | - |
dc.subject.keywordPlus | ORAL DELIVERY | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | BEVACIZUMAB | - |
dc.subject.keywordAuthor | VEGF | - |
dc.subject.keywordAuthor | Anti-flt-1 peptide | - |
dc.subject.keywordAuthor | D-form | - |
dc.subject.keywordAuthor | Mini-PEG | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Chronic arthritis | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
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