DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kataru, RP | - |
dc.contributor.author | Kim, H | - |
dc.contributor.author | Jang, C | - |
dc.contributor.author | Choi, DK | - |
dc.contributor.author | Koh, BI | - |
dc.contributor.author | Kim, M | - |
dc.contributor.author | Gollamudi, S | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Lee, SH | - |
dc.contributor.author | Koh, GY | - |
dc.date.accessioned | 2016-03-31T09:09:38Z | - |
dc.date.available | 2016-03-31T09:09:38Z | - |
dc.date.created | 2011-05-18 | - |
dc.date.issued | 2011-01-28 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.other | 2011-OAK-0000024969 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16738 | - |
dc.description.abstract | Lymph node lymphatic vessels (LNLVs) serve as a conduit to drain antigens from peripheral tissues to within the lymph nodes. LNLV density is known to be positively regulated by vascular endothelial growth factors secreted by B cells, macrophages, and dendritic cells (DCs). Here, we show that LNLV formation was negatively regulated by T cells. In both steady and inflammatory states, the density of LNLVs was increased in the absence of T cells but decreased when T cells were restored. Interferon-gamma secretion by T cells suppressed lymphatic-specific genes in lymphatic endothelial cells and consequently caused marked reduction in LNLV formation. When T cells were depleted, recruitment of antigen-carrying DCs to LNs was augmented, reflecting a compensatory mechanism for antigen presentation to T cells through increased LNLVs. Thus, T cells maintain the homeostatic balance of LNLV density through a negative paracrine action of interferon-gamma. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | IMMUNITY | - |
dc.title | T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.IMMUNI.2010.12.016 | - |
dc.author.google | Kataru, RP | - |
dc.author.google | Kim, H | - |
dc.author.google | Jang, C | - |
dc.author.google | Choi, DK | - |
dc.author.google | Koh, BI | - |
dc.author.google | Kim, M | - |
dc.author.google | Gollamudi, S | - |
dc.author.google | Kim, YK | - |
dc.author.google | Lee, SH | - |
dc.author.google | Koh, GY | - |
dc.relation.volume | 34 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 96 | - |
dc.relation.lastpage | 107 | - |
dc.contributor.id | 10103891 | - |
dc.relation.journal | IMMUNITY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | IMMUNITY, v.34, no.1, pp.96 - 107 | - |
dc.identifier.wosid | 000287336600013 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 107 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 96 | - |
dc.citation.title | IMMUNITY | - |
dc.citation.volume | 34 | - |
dc.contributor.affiliatedAuthor | Kim, YK | - |
dc.contributor.affiliatedAuthor | Koh, GY | - |
dc.identifier.scopusid | 2-s2.0-78751688024 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 113 | - |
dc.description.scptc | 105 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | INDUCED LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | VASCULATURE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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