DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, MN | - |
dc.contributor.author | Koh, A | - |
dc.contributor.author | Park, D | - |
dc.contributor.author | Jang, JH | - |
dc.contributor.author | Kwak, D | - |
dc.contributor.author | Jeon, H | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Choi, EJ | - |
dc.contributor.author | Jeong, H | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2016-03-31T08:51:39Z | - |
dc.date.available | 2016-03-31T08:51:39Z | - |
dc.date.created | 2013-01-31 | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.other | 2013-OAK-0000026226 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16192 | - |
dc.description.abstract | Ras homolog enriched in brain (Rheb) regulates diverse cellular functions by modulating its nucleotide-bound status. Although Rheb contains a high basal GTP level, the regulatory mechanism of Rheb is not well understood. In this study, we propose soluble alpha beta-tubulin acts as a constitutively active Rheb activator, which may explain the reason why Rheb has a high basal GTP levels. We found that soluble alpha beta-tubulin is a direct Rheb-binding protein and that its deacetylated form has a high binding affinity for Rheb. Modulation of both soluble and acetylated alpha beta-tubulin levels affects the level of GTP-bound Rheb. This occurs in the mitotic phase in which the level of acetylated alpha beta-tubulin is increased but that of GTP-bound Rheb is decreased. Constitutively active Rheb-overexpressing cells showed an abnormal mitotic progression, suggesting the deacetylated alpha beta-tubulin-mediated regulation of Rheb status may be important for proper mitotic progression. Taken together, we propose that deacetylated soluble alpha beta-tubulin is a novel type of positive regulator of Rheb and may play a role as a temporal regulator for Rheb during the cell cycle. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | CELLULAR SIGNALLING | - |
dc.subject | Rheb | - |
dc.subject | Soluble tubulin | - |
dc.subject | mTOR | - |
dc.subject | Mitosis | - |
dc.subject | CELL-CYCLE PROGRESSION | - |
dc.subject | RIBOSOME ENTRY SITE | - |
dc.subject | MICROTUBULE DYNAMICS | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | MAMMALIAN TARGET | - |
dc.subject | IN-VIVO | - |
dc.subject | GROWTH | - |
dc.subject | PROTEIN | - |
dc.subject | ACTIVATION | - |
dc.subject | TSC2 | - |
dc.title | Deacetylated alpha beta-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1016/J.CELLSIG.2012.11.006 | - |
dc.author.google | Lee M.N., Koh A., Park D., Jang J.-H., Kwak D., Jeon H., Kim J., Choi E.-J., Jeong H., Suh P.-G., Ryu S.H. | - |
dc.relation.volume | 25 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 539 | - |
dc.relation.lastpage | 551 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | CELLULAR SIGNALLING | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, v.25, no.2, pp.539 - 551 | - |
dc.identifier.wosid | 000313921100016 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 551 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 539 | - |
dc.citation.title | CELLULAR SIGNALLING | - |
dc.citation.volume | 25 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-84875122960 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 3 | - |
dc.description.scptc | 5 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CELL-CYCLE PROGRESSION | - |
dc.subject.keywordPlus | RIBOSOME ENTRY SITE | - |
dc.subject.keywordPlus | MICROTUBULE DYNAMICS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | MAMMALIAN TARGET | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TSC2 | - |
dc.subject.keywordAuthor | Rheb | - |
dc.subject.keywordAuthor | Soluble tubulin | - |
dc.subject.keywordAuthor | mTOR | - |
dc.subject.keywordAuthor | Mitosis | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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