DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, S | - |
dc.contributor.author | Jang, HJ | - |
dc.contributor.author | Park, EH | - |
dc.contributor.author | Kim, JK | - |
dc.contributor.author | Kim, JM | - |
dc.contributor.author | Kim, EK | - |
dc.contributor.author | Yea, K | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Lee-Kwon, W | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-03-31T08:51:26Z | - |
dc.date.available | 2016-03-31T08:51:26Z | - |
dc.date.created | 2013-01-31 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 0730-2312 | - |
dc.identifier.other | 2012-OAK-0000026241 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16185 | - |
dc.description.abstract | Wedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, and pro-apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unknown. Here, we report that wedelolactone inhibits the adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells (hAMSCs). Wedelolactone reduced the formation of lipid droplets and the expression of adipogenesis-related proteins, such as CCAAT enhancer-binding protein-a (C/EBP-a), peroxisome proliferator-activated receptor-? (PPAR-?), lipoprotein lipase (LPL), and adipocyte fatty acid-binding protein aP2 (aP2). Wedelolactone mediated this process by sustaining ERK activity. In addition, inhibition of ERK activity with PD98059 resulted in reversion of the wedelolactone-mediated inhibition of adipogenic differentiation. Taken together, these results indicate that wedelolactone inhibits adipogenic differentiation through ERK pathway and suggest a novel inhibitory effect of wedelolactone on adipogenic differentiation in hAMSCs. J. Cell. Biochem. 113: 34363445, 2012. (C) 2012 Wiley Periodicals, Inc. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.subject | ADIPOGENESIS | - |
dc.subject | MESENCHYMAL STEM CELLS | - |
dc.subject | WEDELOLACTONE | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | MARROW STROMAL CELLS | - |
dc.subject | 3T3-L1 ADIPOCYTE DIFFERENTIATION | - |
dc.subject | N-TERMINAL KINASE | - |
dc.subject | ANDROGEN RECEPTOR | - |
dc.subject | PROSTATE-CANCER | - |
dc.subject | GAMMA PATHWAY | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | PROLIFERATION | - |
dc.title | Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1002/JCB.24220 | - |
dc.author.google | Lim, S | - |
dc.author.google | Jang, HJ | - |
dc.author.google | Park, EH | - |
dc.author.google | Kim, JK | - |
dc.author.google | Kim, JM | - |
dc.author.google | Kim, EK | - |
dc.author.google | Yea, K | - |
dc.author.google | Kim, YH | - |
dc.author.google | Lee-Kwon, W | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 113 | - |
dc.relation.issue | 11 | - |
dc.relation.startpage | 3436 | - |
dc.relation.lastpage | 3445 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR BIOCHEMISTRY, v.113, no.11, pp.3436 - 3445 | - |
dc.identifier.wosid | 000308927200014 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 3445 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3436 | - |
dc.citation.title | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.citation.volume | 113 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-84866503308 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 26 | - |
dc.description.scptc | 23 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | 3T3-L1 ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | N-TERMINAL KINASE | - |
dc.subject.keywordPlus | ANDROGEN RECEPTOR | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | GAMMA PATHWAY | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordAuthor | ADIPOGENESIS | - |
dc.subject.keywordAuthor | MESENCHYMAL STEM CELLS | - |
dc.subject.keywordAuthor | WEDELOLACTONE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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