DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, J | - |
dc.contributor.author | Lee, EY | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Kim, DK | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Kim, KP | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Roh, TY | - |
dc.contributor.author | Gho, YS | - |
dc.date.accessioned | 2016-03-31T08:27:19Z | - |
dc.date.available | 2016-03-31T08:27:19Z | - |
dc.date.created | 2013-07-05 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.other | 2013-OAK-0000028023 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/15343 | - |
dc.description.abstract | Gram-positive bacteria naturally produce extracellular vesicles. However, little is known regarding the functions of Gram-positive bacterial extracellular vesicles, especially in the bacterial community. Here, we investigated the role of Staphylococcus aureus extracellular vesicles in interbacterial communication to cope with antibiotic stress. We found that S. aureus liberated BlaZ, a beta-lactamase protein, via extracellular vesicles. These extracellular vesicles enabled other ampicillin-susceptible Gram-negative and Gram-positive bacteria to survive in the presence of ampicillin. However, S. aureus extracellular vesicles did not mediate the survival of tetracycline-, chloramphenicol-, or kanamycin-susceptible bacteria. Moreover, S. aureus extracellular vesicles did not contain the blaZ gene. In addition, the heat-treated S. aureus extracellular vesicles did not mediate the survival of ampicillin-susceptible bacteria. The beta-lactamase activities of S. aureus soluble and extracellular vesicle-associated BlaZ were similar, but only the extracellular vesicle-associated BlaZ was resistant to protease digestion, which suggests that the enzymatic activity of BlaZ in extracellular vesicles is largely protected by the vesicle structure. Our observations provide evidence of the important role of S. aureus extracellular vesicles in antibiotic resistance, which allows the polymicrobial community to continue to evolve and prosper against antibiotics. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | American Society for Microbiology | - |
dc.relation.isPartOf | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.title | Staphylococcus aureus Extracellular Vesicles Carry Biologically Active beta-Lactamase | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1128/AAC.00522-12 | - |
dc.author.google | Lee, J | - |
dc.author.google | Lee, EY | - |
dc.author.google | Kim, SH | - |
dc.author.google | Kim, DK | - |
dc.author.google | Park, KS | - |
dc.author.google | Kim, KP | - |
dc.author.google | Kim, YK | - |
dc.author.google | Roh, TY | - |
dc.author.google | Gho, YS | - |
dc.relation.volume | 57 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 2589 | - |
dc.relation.lastpage | 2595 | - |
dc.contributor.id | 10138843 | - |
dc.relation.journal | ANTIMICROB AGENTS CHEMOTHER | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.57, no.6, pp.2589 - 2595 | - |
dc.identifier.wosid | 000319272100019 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 2595 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2589 | - |
dc.citation.title | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.citation.volume | 57 | - |
dc.contributor.affiliatedAuthor | Kim, SH | - |
dc.contributor.affiliatedAuthor | Kim, YK | - |
dc.contributor.affiliatedAuthor | Roh, TY | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.identifier.scopusid | 2-s2.0-84877854477 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 41 | - |
dc.description.scptc | 34 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | OUTER-MEMBRANE VESICLES | - |
dc.subject.keywordPlus | PSEUDOMONAS-AERUGINOSA | - |
dc.subject.keywordPlus | NUCLEOTIDE-SEQUENCE | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | PROTEOMICS | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordPlus | GENE | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.