DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, SM | - |
dc.contributor.author | Im, GH | - |
dc.contributor.author | Lee, DG | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Lee, WJ | - |
dc.contributor.author | Lee, IS | - |
dc.date.accessioned | 2016-03-31T08:22:45Z | - |
dc.date.available | 2016-03-31T08:22:45Z | - |
dc.date.created | 2013-12-23 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.other | 2013-OAK-0000028486 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/15171 | - |
dc.description.abstract | With an aim to examine the possibility of developing a liver-specific MRI contrast agent that takes advantages of brightly enhanced MR images by Mn2+ whilst making up the limitations of the pre-developed contrast agent, the Mn2+-doped SiO2 nanoparticles (Mn-SiO2) were synthesized and their characteristics as MR contrast agents were investigated. The in vitro and in vivo investigations showed that Mn-SiO2 has unique MR contrast-enhancing characteristics that activate positive contrast enhancement in T-1-weighted MR images only under low pH conditions by liberating Mn2+ ions from MR inactive nanoparticles. The administration of Mn-SiO2 to an orthotopic xenograft model of human hepatocellular carcinoma (HCC) resulted in a differentiation of enhancement periods between HCC and normal parenchyma tissues on T-1-weighted MR images and consequently presented the duplicates of the highly contrast-enhanced liver image with an equal liver-to-HCC contrast ratio but opposite contrast. The Mn-SiO2-enhanced MR imaging therefore allowed for the repetitive detection of the HCC within a single MR imaging session, which can help us to achieve more reliable diagnosis and characterization of liver lesions than is possible with any currently used Mn2+-based contrast agent. In addition, the in vivo biodistribution study also supported the effectiveness of Mn-SiO2 nanoparticles as a liver-specific MRI contrast agent, which efficiently delivers and releases the T-1-contrasting Mn2+ ions to targeted hepatocytes. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.subject | Nanoparticle | - |
dc.subject | MRI (magnetic resonance imaging) | - |
dc.subject | Contrast agent | - |
dc.subject | Liver | - |
dc.subject | Manganese | - |
dc.subject | Silica | - |
dc.subject | MANGANESE OXIDE NANOPARTICLES | - |
dc.subject | NEPHROGENIC SYSTEMIC FIBROSIS | - |
dc.subject | SUPERPARAMAGNETIC IRON-OXIDE | - |
dc.subject | IN-VIVO BIODISTRIBUTION | - |
dc.subject | CONTRAST AGENTS | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | CELLULAR MRI | - |
dc.subject | MNDPDP | - |
dc.subject | PHARMACOKINETICS | - |
dc.subject | NANOCRYSTALS | - |
dc.title | Mn2+-doped silica nanoparticles for hepatocyte-targeted detection of liver cancer in T-1-weighted MRI | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1016/J.BIOMATERIALS.2013.08.009 | - |
dc.author.google | Kim, SM | - |
dc.author.google | Im, GH | - |
dc.author.google | Lee, DG | - |
dc.author.google | Lee, JH | - |
dc.author.google | Lee, WJ | - |
dc.author.google | Lee, IS | - |
dc.relation.volume | 34 | - |
dc.relation.issue | 35 | - |
dc.relation.startpage | 8941 | - |
dc.relation.lastpage | 8948 | - |
dc.contributor.id | 10179922 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.34, no.35, pp.8941 - 8948 | - |
dc.identifier.wosid | 000324783000010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 8948 | - |
dc.citation.number | 35 | - |
dc.citation.startPage | 8941 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 34 | - |
dc.contributor.affiliatedAuthor | Lee, IS | - |
dc.identifier.scopusid | 2-s2.0-84883223901 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 22 | - |
dc.description.scptc | 20 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MANGANESE OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | NEPHROGENIC SYSTEMIC FIBROSIS | - |
dc.subject.keywordPlus | SUPERPARAMAGNETIC IRON-OXIDE | - |
dc.subject.keywordPlus | IN-VIVO BIODISTRIBUTION | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | CELLULAR MRI | - |
dc.subject.keywordPlus | MNDPDP | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordAuthor | Nanoparticle | - |
dc.subject.keywordAuthor | MRI (magnetic resonance imaging) | - |
dc.subject.keywordAuthor | Contrast agent | - |
dc.subject.keywordAuthor | Liver | - |
dc.subject.keywordAuthor | Manganese | - |
dc.subject.keywordAuthor | Silica | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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