DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shemorry, A | - |
dc.contributor.author | Hwang, CS | - |
dc.contributor.author | Varshavsky, A | - |
dc.date.accessioned | 2016-03-31T08:17:59Z | - |
dc.date.available | 2016-03-31T08:17:59Z | - |
dc.date.created | 2014-02-19 | - |
dc.date.issued | 2013-05-23 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.other | 2013-OAK-0000028881 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14997 | - |
dc.description.abstract | N-alpha-terminal acetylation of cellular proteins was recently discovered to create specific degradation signals termed Ac/N-degrons and targeted by the Ac/N-end rule pathway. We show that Hcn1, a subunit of the APC/C ubiquitin ligase, contains an Ac/N-degron that is repressed by Cut9, another APC/C subunit and the ligand of Hcn1. Cog1, a subunit of the Golgi-associated COG complex, is also shown to contain an Ac/N-degron. Cog2 and Cog3, direct ligands of Cog1, can repress this degron. The subunit decoy technique was used to show that the long-lived endogenous Cog1 is destabilized and destroyed via its activated (unshielded) Ac/N-degron if the total level of Cog1 increased in a cell. Hurl and Cog1 are the first examples of protein regulation through the physiologically relevant transitions that shield and unshield natural Ac/N-degrons. This mechanistically straightforward circuit can employ the demonstrated conditionality of Ac/N-degrons to regulate subunit stoichiometries and other aspects of protein quality control. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | Molecular Cell | - |
dc.subject | UBIQUITIN-PROTEASOME SYSTEM | - |
dc.subject | DEGRADATION SIGNALS | - |
dc.subject | COMPLEX | - |
dc.subject | YEAST | - |
dc.subject | ACETYLTRANSFERASES | - |
dc.subject | SUBUNIT | - |
dc.subject | RECOGNITION | - |
dc.subject | PROTEOLYSIS | - |
dc.subject | EXPRESSION | - |
dc.subject | RIBOSOME | - |
dc.title | Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.MOLCEL.2013.03.018 | - |
dc.author.google | Shemorry, A | - |
dc.author.google | Hwang, CS | - |
dc.author.google | Varshavsky, A | - |
dc.relation.volume | 50 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 540 | - |
dc.relation.lastpage | 551 | - |
dc.contributor.id | 10966770 | - |
dc.relation.journal | Molecular Cell | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Molecular Cell, v.50, no.4, pp.540 - 551 | - |
dc.identifier.wosid | 000319893600009 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 551 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 540 | - |
dc.citation.title | Molecular Cell | - |
dc.citation.volume | 50 | - |
dc.contributor.affiliatedAuthor | Hwang, CS | - |
dc.identifier.scopusid | 2-s2.0-84878195272 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 113 | - |
dc.description.scptc | 89 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | ACETYLTRANSFERASES | - |
dc.subject.keywordPlus | SUBUNIT | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RIBOSOME | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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