DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, H | - |
dc.contributor.author | Lee, MY | - |
dc.contributor.author | Bhang, SH | - |
dc.contributor.author | Kim, BS | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Ju, JH | - |
dc.contributor.author | Kim, KS | - |
dc.contributor.author | Hahn, SK | - |
dc.date.accessioned | 2016-03-31T08:00:36Z | - |
dc.date.available | 2016-03-31T08:00:36Z | - |
dc.date.created | 2014-10-08 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.other | 2014-OAK-0000030379 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14358 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is a chronic inflammatory immune disease causing the inflammation of synovial membrane and the articular cartilage destruction. In this work, hyaluronate gold nanoparticle/Tocilizumab (HA-AuNP/TCZ) complex was prepared for the treatment of RA. AuNP was used as a drug carrier with antiangiogenic effect. in is a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor and used as an immunosuppressive drug by Interfering IL-6 in the pathogenesis of RA. HA is known to have cartilage-protective and lubricant effects. HA was modified with cystamine via reductive amination, which was reduced with dithiothreitol (DTT) to prepare end-group thiolated HA (HA-SH). AuNP was chemically modified with HA-SH and physically modified with T. The formation of HA-AuNP/TCZ complex was corroborated by UV-vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The therapeutic effect of HA-AuNP/TCZ complex on RA was confirmed In collagen-induced arthritis (CIA) model mice by ELISA, histological, and Western blot analyses. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS NANO | - |
dc.subject | gold nanoparticle | - |
dc.subject | tocilizumab | - |
dc.subject | hyaluronic acid | - |
dc.subject | drug delivery | - |
dc.subject | rheumatoid arthritis | - |
dc.subject | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject | RECEPTOR INHIBITION | - |
dc.subject | NANOPARTICLES | - |
dc.subject | TOCILIZUMAB | - |
dc.subject | THERAPY | - |
dc.subject | ACID | - |
dc.subject | DISEASE | - |
dc.title | Hyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.contributor.college | 신소재공학과 | - |
dc.identifier.doi | 10.1021/NN500685H | - |
dc.author.google | Lee, H | - |
dc.author.google | Lee, MY | - |
dc.author.google | Bhang, SH | - |
dc.author.google | Kim, BS | - |
dc.author.google | Kim, YS | - |
dc.author.google | Ju, JH | - |
dc.author.google | Kim, KS | - |
dc.author.google | Hahn, SK | - |
dc.relation.volume | 8 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 4790 | - |
dc.relation.lastpage | 4798 | - |
dc.contributor.id | 10149037 | - |
dc.relation.journal | ACS NANO | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACS NANO, v.8, no.5, pp.4790 - 4798 | - |
dc.identifier.wosid | 000336640600069 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 4798 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 4790 | - |
dc.citation.title | ACS NANO | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.identifier.scopusid | 2-s2.0-84901649576 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 44 | - |
dc.description.scptc | 37 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | RECEPTOR INHIBITION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | TOCILIZUMAB | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | gold nanoparticle | - |
dc.subject.keywordAuthor | tocilizumab | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.