DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, JH | - |
dc.contributor.author | Yoon, MC | - |
dc.contributor.author | Jeong, CM | - |
dc.contributor.author | Jang, J | - |
dc.contributor.author | Jeong, SI | - |
dc.contributor.author | Cho, DW | - |
dc.contributor.author | Huh, JB | - |
dc.date.accessioned | 2016-03-31T07:57:38Z | - |
dc.date.available | 2016-03-31T07:57:38Z | - |
dc.date.created | 2015-01-20 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.other | 2014-OAK-0000030741 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14250 | - |
dc.description.abstract | We successfully fabricated a three-dimensional (3D) printing-based PCL/PLGA/beta-TCP guided bone regeneration (GBR) membrane that slowly released rhBMP-2. To impregnate the GBR membrane with intact rhBMP-2, collagen solution encapsulating rhBMP-2 (5 mu g ml(-1)) was infused into pores of a PCL/PLGA/beta-TCP membrane constructed using a 3D printing system with four dispensing heads. In a release profile test, sustained release of rhBMP-2 was observed for up to 28 d. To investigate the efficacy of the GBR membrane on bone regeneration, PCL/PLGA/beta-TCP membranes with or without rhBMP-2 were implanted in an 8 mm calvaria defect of rabbits. Bone formation was evaluated at weeks 4 and 8 histologically and histomorphometrically. A space making ability of the GBR membrane was successfully maintained in both groups, and significantly more new bone was formed at post-implantation weeks 4 and 8 by rhBMP-2 loaded GBR membranes. Interestingly, implantation with rhBMP-2 loaded GBR membranes led to almost entire healing of calvaria defects within 8 weeks. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.relation.isPartOf | BIOMEDICAL MATERIALS | - |
dc.subject | guided bone regeneration membrane | - |
dc.subject | 3D printing | - |
dc.subject | bone morphogenetic proteins-2 (BMP-2) | - |
dc.subject | calvaria defect | - |
dc.subject | MORPHOGENETIC PROTEIN-2 | - |
dc.subject | PERI-IMPLANT | - |
dc.subject | SOFT-TISSUE | - |
dc.subject | PORE-SIZE | - |
dc.subject | IN-VIVO | - |
dc.subject | SCAFFOLD | - |
dc.subject | BMP-2 | - |
dc.subject | OSTEOGENESIS | - |
dc.subject | PRINCIPLE | - |
dc.subject | DELIVERY | - |
dc.title | Efficacy of rhBMP-2 loaded PCL/PLGA/beta-TCP guided bone regeneration membrane fabricated by 3D printing technology for reconstruction of calvaria defects in rabbit | - |
dc.type | Article | - |
dc.contributor.college | 기계공학과 | - |
dc.identifier.doi | 10.1088/1748-6041/9/6/065006 | - |
dc.author.google | Shim, JH | - |
dc.author.google | Yoon, MC | - |
dc.author.google | Jeong, CM | - |
dc.author.google | Jang, J | - |
dc.author.google | Jeong, SI | - |
dc.author.google | Cho, DW | - |
dc.author.google | Huh, JB | - |
dc.relation.volume | 9 | - |
dc.relation.issue | 6 | - |
dc.contributor.id | 10102903 | - |
dc.relation.journal | BIOMEDICAL MATERIALS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMEDICAL MATERIALS, v.9, no.6 | - |
dc.identifier.wosid | 000345615600007 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.number | 6 | - |
dc.citation.title | BIOMEDICAL MATERIALS | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Cho, DW | - |
dc.identifier.scopusid | 2-s2.0-84914126680 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 28 | - |
dc.description.scptc | 27 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | PERI-IMPLANT | - |
dc.subject.keywordPlus | SOFT-TISSUE | - |
dc.subject.keywordPlus | PORE-SIZE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | OSTEOGENESIS | - |
dc.subject.keywordPlus | PRINCIPLE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordAuthor | guided bone regeneration membrane | - |
dc.subject.keywordAuthor | 3D printing | - |
dc.subject.keywordAuthor | bone morphogenetic proteins-2 (BMP-2) | - |
dc.subject.keywordAuthor | calvaria defect | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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