DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, BA | - |
dc.contributor.author | Ko, Y | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Choi, MS | - |
dc.contributor.author | Kim, IS | - |
dc.contributor.author | Kim, HR | - |
dc.contributor.author | Cho, NH | - |
dc.date.accessioned | 2015-06-25T03:23:21Z | - |
dc.date.available | 2015-06-25T03:23:21Z | - |
dc.date.created | 2013-02-01 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 1935-2735 | - |
dc.identifier.other | 2015-OAK-0000026247 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/12642 | - |
dc.description.abstract | Background: Scrub typhus, caused by Orientia tsutsugamushi infection, is one of the main causes of febrile illness in the Asia-Pacific region. Although cell-mediated immunity plays an important role in protection, little is known about the phenotypic changes and dynamics of leukocytes in scrub typhus patients. Methodology/Principal Findings: To reveal the underlying mechanisms of immunological pathogenesis, we extensively analyzed peripheral blood leukocytes, especially T cells, during acute and convalescent phases of infection in human patients and compared with healthy volunteers. We observed neutrophilia and CD4(+) T lymphopenia in the acute phase of infection, followed by proliferation of CD8(+) T cells during the convalescent phase. Massive T cell apoptosis was detected in the acute phase and preferential increase of CD8(+) T cells with activated phenotypes was observed in both acute and convalescent phases, which might be associated or correlated with elevated serum IL-7 and IL-15. Interestingly, peripheral Treg cells were significantly down-regulated throughout the disease course. Conclusions/Significance: The remarkable decrease of CD4(+) T cells, including Treg cells, during the acute phase of infection may contribute to the loss of immunological memory that are often observed in vaccine studies and recurrent human infection. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS NEGLECTED TROPICAL DISEASES | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Phenotypic characterization of peripheral T cells and their dynamics in scrub typhus patients | - |
dc.type | Article | - |
dc.contributor.college | 정보전자융합공학부 | en_US |
dc.identifier.doi | 10.1371/journal.pntd.0001789 | - |
dc.author.google | Cho, BA | en_US |
dc.author.google | Ko, Y | en_US |
dc.author.google | Cho, NH | en_US |
dc.author.google | Kim, HR | en_US |
dc.author.google | Kim, IS | en_US |
dc.author.google | Choi, MS | en_US |
dc.author.google | Kim, S | en_US |
dc.author.google | Kim, YS | en_US |
dc.relation.volume | 6 | en_US |
dc.relation.issue | 8 | en_US |
dc.contributor.id | 10136479 | en_US |
dc.relation.journal | PLOS NEGLECTED TROPICAL DISEASES | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PLOS NEGLECTED TROPICAL DISEASES, v.6, no.8 | - |
dc.identifier.wosid | 000308497100025 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.number | 8 | - |
dc.citation.title | PLOS NEGLECTED TROPICAL DISEASES | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Kim, S | - |
dc.identifier.scopusid | 2-s2.0-84865988443 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 19 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ORIENTIA-TSUTSUGAMUSHI INFECTION | - |
dc.subject.keywordPlus | RICKETTSIA-TSUTSUGAMUSHI | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | CYNOMOLGUS MONKEYS | - |
dc.subject.keywordPlus | GAMMA-INTERFERON | - |
dc.subject.keywordPlus | CHEMOKINE GENES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CD8(+) | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Tropical Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalResearchArea | Tropical Medicine | - |
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