경두개 자기 자극의 기전 연구를 위한 세포 실험용 코일 디자인 및 검증 실험

Abstract

Transcranial magnetic stimulation (TMS) is a safe non-invasive brain stimulation technique for neurological disorders. However, the underlying cellular mechanisms remain poorly understood. In this study, we proposed the magnetic coil design suitable for in vitro experiments and conducted a simple verification experiment with neuronal cell line. Using a computational electromagnetic simulation, we confirmed that our proposed the spiral modified Helmholtz coil could generate the enough field intensity to modulate neuronal excitability. For verification of our coil design, we constructed the designed coil and stimulation device, and stimulated neuronal cell line with our custom-built system. Our in vitro experiment with the custom-built system confirmed frequency-dependent TMS effects.