DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park Y. | - |
dc.contributor.author | Park J. | - |
dc.contributor.author | Hwang H.J. | - |
dc.contributor.author | Kim B. | - |
dc.contributor.author | Jeong K. | - |
dc.contributor.author | Chang J. | - |
dc.contributor.author | Lee J.-B. | - |
dc.contributor.author | Kim Y.K. | - |
dc.date.accessioned | 2021-09-30T04:50:38Z | - |
dc.date.available | 2021-09-30T04:50:38Z | - |
dc.date.created | 2020-07-23 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/107208 | - |
dc.description.abstract | Nonsense-mediated mRNA decay (NMD) typifies an mRNA surveillance pathway. Because NMD necessitates a translation event to recognize a premature termination codon on mRNAs, truncated misfolded polypeptides (NMD-polypeptides) could potentially be generated from NMD substrates as byproducts. Here, we show that when the ubiquitin–proteasome system is overwhelmed, various misfolded polypeptides including NMD-polypeptides accumulate in the aggresome: a perinuclear nonmembranous compartment eventually cleared by autophagy. Hyperphosphorylation of the key NMD factor UPF1 is required for selective targeting of the misfolded polypeptide aggregates toward the aggresome via the CTIF–eEF1A1–DCTN1 complex: the aggresome-targeting cellular machinery. Visualization at a single-particle level reveals that UPF1 increases the frequency and fidelity of movement of CTIF aggregates toward the aggresome. Furthermore, the apoptosis induced by proteotoxic stresses is suppressed by UPF1 hyperphosphorylation. Altogether, our data provide evidence that UPF1 functions in the regulation of a protein surveillance as well as an mRNA quality control. © 2020, The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Research | - |
dc.relation.isPartOf | Nature Communications | - |
dc.title | Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-020-16939-6 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Nature Communications, v.11, no.1 | - |
dc.identifier.wosid | 000545685100003 | - |
dc.citation.number | 1 | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | Kim B. | - |
dc.contributor.affiliatedAuthor | Lee J.-B. | - |
dc.identifier.scopusid | 2-s2.0-85086655265 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | aggresome | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | cannulation | - |
dc.subject.keywordPlus | cell culture | - |
dc.subject.keywordPlus | cell migration | - |
dc.subject.keywordPlus | codon | - |
dc.subject.keywordPlus | comparative study | - |
dc.subject.keywordPlus | confocal microscopy | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | down regulation | - |
dc.subject.keywordPlus | gene amplification | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | gene overexpression | - |
dc.subject.keywordPlus | genetic transfection | - |
dc.subject.keywordPlus | HEK293T cell line | - |
dc.subject.keywordPlus | HeLa cell line | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | human tissue | - |
dc.subject.keywordPlus | immunohistochemistry | - |
dc.subject.keywordPlus | complementary DNA | - |
dc.subject.keywordPlus | messenger RNA | - |
dc.subject.keywordPlus | ribonuclease | - |
dc.subject.keywordPlus | small interfering RNA | - |
dc.subject.keywordPlus | ubiquitin | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | protein | - |
dc.subject.keywordPlus | quality control | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | visualization | - |
dc.subject.keywordPlus | immunoprecipitation | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | nonsense mediated mRNA decay | - |
dc.subject.keywordPlus | plasmid | - |
dc.subject.keywordPlus | polyacrylamide gel electrophoresis | - |
dc.subject.keywordPlus | protein binding | - |
dc.subject.keywordPlus | protein misfolding | - |
dc.subject.keywordPlus | protein phosphorylation | - |
dc.subject.keywordPlus | protein quality | - |
dc.subject.keywordPlus | quality control | - |
dc.subject.keywordPlus | real time reverse transcription polymerase chain reaction | - |
dc.subject.keywordPlus | receptor down regulation | - |
dc.subject.keywordPlus | TUNEL assay | - |
dc.subject.keywordPlus | Western blotting | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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