DC Field | Value | Language |
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dc.contributor.author | HONG, HYEONJUN | - |
dc.contributor.author | Kim, Dong Sung | - |
dc.date.accessioned | 2021-02-09T01:50:16Z | - |
dc.date.available | 2021-02-09T01:50:16Z | - |
dc.date.created | 2021-01-20 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2079-4991 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/105024 | - |
dc.description.abstract | The topographical micro-patterning of nanofibrillar collagen gels is promising for the fabrication of biofunctional constructs mimicking topographical cell microenvironments of in vivo extracellular matrices. Nevertheless, obtaining structurally robust collagen micro-patterns through this technique is still a challenging issue. Here, we report a novel in situ photochemical crosslinking-assisted collagen embossing (IPC-CE) process as an integrative fabrication technique based on collagen compression-based embossing and UV-riboflavin crosslinking. The IPC-CE process using a micro-patterned polydimethylsiloxane (PDMS) master mold enables the compaction of collagen nanofibrils into micro-cavities of the mold and the simultaneous occurrence of riboflavin-mediated photochemical reactions among the nanofibrils, resulting in a robust micro-patterned collagen construct. The micro-patterned collagen construct fabricated through the IPC-CE showed a remarkable mechanical resistivity against rehydration and manual handling, which could not be achieved through the conventional collagen compression-based embossing alone. Micro-patterns of various sizes (minimum feature size <10 mu m) and shapes could be obtained by controlling the compressive pressure (115 kPa) and the UV dose (3.00 J/cm(2)) applied during the process. NIH 3T3 cell culture on the micro-patterned collagen construct finally demonstrated its practical applicability in biological applications, showing a notable effect of anisotropic topography on cells in comparison with the conventional construct. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Nanomaterials | - |
dc.title | Robust Topographical Micro-Patterning of Nanofibrillar Collagen Gel by In Situ Photochemical Crosslinking-Assisted Collagen Embossing | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/nano10122574 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Nanomaterials, v.10, no.12 | - |
dc.identifier.wosid | 000602630800001 | - |
dc.citation.number | 12 | - |
dc.citation.title | Nanomaterials | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | HONG, HYEONJUN | - |
dc.contributor.affiliatedAuthor | Kim, Dong Sung | - |
dc.identifier.scopusid | 2-s2.0-85098534827 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BIOMIMETIC MATERIALS | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | LAYER | - |
dc.subject.keywordPlus | MORPHOLOGY | - |
dc.subject.keywordPlus | GROOVES | - |
dc.subject.keywordAuthor | cell microenvironments | - |
dc.subject.keywordAuthor | nanofibrillar collagen gel | - |
dc.subject.keywordAuthor | micro-patterning | - |
dc.subject.keywordAuthor | collagen compression | - |
dc.subject.keywordAuthor | collagen embossing | - |
dc.subject.keywordAuthor | photochemical crosslinking | - |
dc.subject.keywordAuthor | cell culture scaffold | - |
dc.subject.keywordAuthor | anisotropic topography | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
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